Structural insights into bacterial recognition of intestinal mucins
Structural insights into bacterial recognition of intestinal mucins
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DOI：
10.1016/j.sbi.2014.07.002
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发表时间：
2014-10-01
影响因子：
6.8
通讯作者：
Juge, Nathalie
中科院分区：
文献类型：
--
作者：
Etzold, Sabrina;Juge, Nathalie
覆盖在肠道上皮上的粘膜层是宿主抵御腔内容物的第一道防线，同时使驻留的微生物群与宿主之间能够接触。粘液主要由粘蛋白、含有蛋白核心的大糖蛋白和大量O-连接的低聚糖组成。粘蛋白多糖作为肠道微生物的结合部位或碳源，从而发挥影响微生物区系组成和人类健康的宿主特异性决定因素的作用。由于粘蛋白多糖及其主要位置的结构多样性，共生微生物和病原微生物进化出一系列粘附素，使它们能够与宿主相互作用。然而，尽管粘蛋白多糖在调节肠道内环境稳定方面的重要性得到了认可，但有关肠道细菌的碳水化合物结合蛋白的信息却是不同的。这篇综述集中在粘蛋白介导的宿主-微生物相互作用的最新结构洞察。
The mucosal layer covering our gut epithelium represents the first line of host defenses against the luminal content, while enabling contacts between the resident microbiota and the host. Mucus is mainly composed of mucins, large glycoproteins containing a protein core and a high number of O-linked oligosaccharides. Mucin glycans act as binding sites or carbon sources for the intestinal microbes, thereby functioning as a host-specific determinant affecting the microbiota composition and human health. Reflecting the structural diversity of mucin glycans and their prime location, commensal and pathogenic microbes have evolved a range of adhesins allowing their interaction with the host. However, despite the recognised importance of mucin glycans in modulating intestinal homeostasis, information on carbohydrate-binding proteins from gut bacteria is disparate. This review is focussed on recent structural insights into host-microbe interactions mediated by mucins.