Association analysis between Tourette's syndrome and dopamine D1 receptor gene in Taiwanese children
Association analysis between Tourette's syndrome and dopamine D1 receptor gene in Taiwanese children
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DOI：
10.1097/00041444-200412000-00010
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发表时间：
2004-12-01
影响因子：
0.9
通讯作者：
Tsai, FJ
中科院分区：
文献类型：
--
作者：
Chou, IC;Tsai, CH;Tsai, FJ
目的近年来的研究表明，抽动秽语综合征（TS）可能是多巴胺系统缺陷所致。多巴胺1受体（DRD 1）基因是研究多巴胺能异常神经精神疾病病因的候选基因。我们试图检验的假设，DRD 1基因可能发挥作用，在TS。方法通过进行关联研究，我们收集了一个独立的样本，从台湾的米德兰地区的患者，并调查是否DRD 1基因多态性可以被用作标记TS的易感性。共纳入148名TS儿童和83名正常对照组。采用聚合酶链反应（PCR）技术检测DRD 1基因的A/G多态性。结果DRD 1基因多态性的基因型和等位基因频率在两组间差异无统计学意义结论DRD 1基因可能不是TS易感性的预测指标。(C)2004年利平科特威廉姆斯威尔金斯。
Objective Recent research suggests that Tourette's syndrome (TS) may result from a defect in the dopamine system. The dopamine 1 receptor (DRD1) gene is a candidate gene in the study of the etiology of neuropsychiatric diseases that may involve dopaminergic abnormalities. We sought to test the hypothesis that the DRD1 gene might play a role in TS.Methods By performing an association study, we collected an independent sample of patients from the midland region of Taiwan and investigated whether DRD1 gene polymorphisms can be used as markers of susceptibility to TS. A total of 148 children with TS and 83 normal control subjects were included in the study. A polymerase chain reaction was used to identify the A/G polymorphism of the DRD1 gene. Genotypes and allelic frequencies for the DRD1 gene polymorphisms in both groups were compared.Results The results showed that genotypes and allelic frequencies for the DRD1 gene polymorphisms in both groups were not significantly different.Conclusion These data suggest that DRD1 gene may not be a useful marker for prediction of the susceptibility of TS. (C) 2004 Lippincott Williams Wilkins.