Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension.
Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension.
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DOI：
10.1161/atvbaha.118.311229
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Isakson BE
中科院分区：
文献类型：
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作者：
Brown IAM;Diederich L;Good ME;DeLalio LJ;Murphy SA;Cortese-Krott MM;Hall JL;Le TH;Isakson BE
心血管疾病是全世界死亡的主要原因，每年造成超过1730万人死亡，估计到2030年发病率将增加到2360万。心血管死亡占全球所有死亡的31%-中风、心脏病发作和动脉瘤破裂是导致这些高死亡率的主要原因。心血管疾病的一个关键危险因素是高血压。虽然治疗或降低高血压可以预防心血管事件的发生，但现有的治疗方法仅部分有效。高血压的一个关键病理标志是由于大（传导）和小（阻力）动脉的结构和功能变化而导致的外周血管阻力增加。本文就高血压患者血管重构的临床意义、传导动脉和阻力动脉血管平滑肌细胞（VSMC）重构的差异、与VSMC功能相关的遗传因素进行了综述，并对高血压治疗的研究现状和药物靶点进行了展望。
Cardiovascular disease is a leading cause of death worldwide and accounts for greater than 17.3 million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 . Cardiovascular death represents 31% of all global deaths - with stroke, heart attack, and ruptured aneurysms predominantly contributing to these high mortality rates. A key risk factor for cardiovascular disease is hypertension. Although treatment or reduction in hypertension can prevent the onset of cardiovascular events, existing therapies are only partially effective. A key pathological hallmark of hypertension is increased peripheral vascular resistance due to structural and functional changes in large (conductive) and small (resistance) arteries. In this review, we discuss the clinical implications of vascular remodeling, compare the differences between vascular smooth muscle cell (VSMC) remodeling in conductive and resistance arteries, discuss the genetic factors associated with VSMC function in hypertensive patients, and provide a prospective assessment of current and future research and pharmacological targets for the treatment of hypertension.