Double nerve intraneural interface implant on a human amputee for robotic hand control
Double nerve intraneural interface implant on a human amputee for robotic hand control
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DOI：
10.1016/j.clinph.2010.01.001
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发表时间：
2010-05-01
影响因子：
4.7
通讯作者：
Dario, Paolo
中科院分区：
文献类型：
--
作者：
Rossini, Paolo M.;Micera, Silvestro;Dario, Paolo
目的：该项目的基本原理是，尽管上肢截肢后神经重组，但原始通路和CNS中继部分保持其功能，并可用于接口prosthesies. The目的是评估一种新型外周神经内多电极用于多运动假肢控制和感觉反馈，同时评估重新获取的数据流后的皮层重组。方法：四个束内纵行。灵活的多电极（tf-LIFE 4）被植入截肢者的正中神经和尺神经，他们可靠地记录输出信号4周。人工智能分类器离线分析LIFE信号记录在三个不同的手动作自愿order.Results：实时控制电机输出的三个动作。应用离线人工智能时，试验的实时正确分类率达到>85%。此外，确定不同类型的电流刺激以允许可再现和局部化的手/手指感觉。皮层组织观察通过TMS在平行的部分解决的症状，由于幻肢综合征（PLS）。结论：TF-LIFE 4s记录输出信号在人类神经4周，虽然感觉刺激的效果衰减后10天。记录从一些纤维允许高百分比的不同的行动被正确分类。塑料的变化和缓解PLS的restoration代表的潜在therapeutic benefit.Significance的必然结果：这项研究代表了一个突破，在截肢者的机器人手的使用。(C)2010年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objectives: The principle underlying this project is that, despite nervous reorganization following upper limb amputation, original pathways and CNS relays partially maintain their function and can be exploited for interfacing prostheses.Aim of this study is to evaluate a novel peripheral intraneural multielectrode for multi-movement prosthesis control and for sensory feed-back, while assessing cortical reorganization following the reacquired stream of data.Methods: Four intrafascicular longitudinal. exible multielectrodes (tf-LIFE4) were implanted in the median and ulnar nerves of an amputee; they reliably recorded output signals for 4 weeks. Artificial intelligence classifiers were used off-line to analyse LIFE signals recorded during three distinct hand movements under voluntary order.Results: Real-time control of motor output was achieved for the three actions. When applied off-line artificial intelligence reached >85% real-time correct classification of trials. Moreover, different types of current stimulation were determined to allow reproducible and localized hand/fingers sensations. Cortical organization was observed via TMS in parallel with partial resolution of symptoms due to the phantomlimb syndrome (PLS).Conclusions: tf-LIFE4s recorded output signals in human nerves for 4 weeks, though the efficacy of sensory stimulation decayed after 10 days. Recording from a number of fibres permitted a high percentage of distinct actions to be classified correctly. Reversal of plastic changes and alleviation of PLS represent corollary findings of potential therapeutic benefit.Significance: This study represents a breakthrough in robotic hand use in amputees. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.