The Eradication of Helicobacter pylori is Affected by Body Mass Index (BMI)
The Eradication of Helicobacter pylori is Affected by Body Mass Index (BMI)
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DOI：
10.1007/s11695-008-9477-z
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发表时间：
2008-11-01
期刊：
影响因子：
2.9
通讯作者：
Severi, Carola
中科院分区：
文献类型：
--
作者：
Abdullahi, Mohamed;Annibale, Bruno;Severi, Carola
背景：由于幽门螺杆菌阳性患者术后溃疡和前庭症状的风险增加，减肥外科医生通常主张术前检测和根除幽门螺杆菌。方法将81例非糖尿病单纯幽门螺杆菌阳性患者按BMI分为两组，正常对照组41例，超重/肥胖组40例。进行胃镜检查，并从胃窦和胃体获得多次活组织检查。两组均给予潘托拉唑40 mg，疗程2周，加阿莫西林1g，tid；克拉霉素250 mg，tid，疗程1周。结果超重/肥胖组有效率为55.0%，超重/肥胖组为85.4%，差异有统计学意义(P
Background Bariatric surgeons often advocate preoperative Helicobacter pylori (H. pylori) testing and eradication because of the increased risk of postoperative ulcers and foregut symptoms in H. pylori-positive patients. The aim of this pilot study was to evaluate whether body mass index (BMI) might influence the success rate of eradication.Methods Eighty one nondiabetic naive H. pylori-positive patients were divided into two groups according to their BMI, with 41 in the control group (normal BMI) and 40 in the overweight/obese group (BMI >= N25). Gastroscopy was performed and multiple biopsies were obtained from the antrum and corpus. Both groups were given a triple therapy consisting of pantoprazole 40 mg for 2 weeks plus amoxicillin 1 g tris in die (t.i.d), and clarithromycin 250 mg t.i.d, for the first week of treatment. Eradication was confirmed by the C-13-urea breath test at 3 months.Results Successful eradication was observed in 55.0% of the overweight/obese group compared with 85.4% [p