Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: Initial and chronic exposure
Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: Initial and chronic exposure
复制标题
DOI：
10.1016/s0893-133x(01)00427-4
复制
发表时间：
2002-07-01
影响因子：
7.6
通讯作者：
Porrino, LJ
中科院分区：
文献类型：
--
作者：
Nader, MA;Daunais, JB;Porrino, LJ
本研究的目的是检查多巴胺D-1和D-2样受体密度的变化在猴子自我管理可卡因的时间过程。根据剂量（0.03或0.3 mg/kg/注射）和暴露持续时间（5或类似于100次），将未经实验的成年雄性恒河猴（n = 22）分为食物强化组（n = 6），其中通过食物提供维持反应，或分为4个可卡因自我给药组（n = 4/组）。在最后一次治疗后，对猴实施安乐死，取出大脑，冷冻，并处理通过纹状体、吻侧至前连合的冠状切片，用于D-1（[H-3] SCH 23390）和D-2（[H-3]雷氯必利）受体放射自显影。与对照组相比，5天的可卡因自我给药对D1和D2受体没有影响。在具有广泛可卡因历史的猴子中，相对于纹状体的某些部分中的对照，D1受体密度显著增加，而D2受体密度在整个纹状体中显著降低。这些研究结果表明，长期可卡因自我管理产生多巴胺系统的神经适应，但这些变化不会以平行的方式发生。(C)2002年美国神经精神药理学学会。出版社：Elsevier Science Inc.
The purpose of this study was to examine the time course of changes in dopamine D-1- and D-2-like receptor densities in monkeys self-administering cocaine. Experimentally naive adult male rhesus monkeys (n = 22) were divided into a food reinforcement group (n = 6), in which responding was maintained by food presentation, or into four cocaine self-administration groups (n = 4/group), based on dose (0.03 or 0.3 mg/kg per injection) and duration of exposure (5 or similar to100 sessions). After the last session, monkeys were euthanized, brains were removed, frozen, and coronal sections through the striation, rostral to the anterior commissure, were processed for D-1 ([H-3]SCH23390) and D-2 ([H-3]raclopride) receptor autoradiography. Compared with controls, there was no effect of 5 days of cocaine self-administration on D, and D2 receptors. In monkeys with extensive cocaine histories, D, receptor densities were significantly increased relative to controls in some parts of the striatum, while D2 receptor densities were significantly decreased throughout the striatum. These findings demonstrate that chronic cocaine self-administration produces neuroadaptations in dopamine systems, but that these changes do not occur in a parallel fashion. (C) 2002 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.