The importance of insulin-like growth factor (somatomedin) measurements in the diagnosis and surveillance of acromegaly.
The importance of insulin-like growth factor (somatomedin) measurements in the diagnosis and surveillance of acromegaly.
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胰岛素样生长因子（生长调节素）测量在肢端肥大症诊断和监测中的重要性。
DOI：
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发表时间：
1982
影响因子：
5.8
通讯作者：
M. Binoux
中科院分区：
文献类型：
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作者：
M. Rieu;F. Girard;H. Bricaire;M. Binoux
在醋酸凝胶过滤后，通过竞争性蛋白结合测定法，使用培养物中大鼠肝脏产生的特异性结合蛋白和人 IGF-I 作为示踪剂，测量了 92 名肢端肥大症患者的血清生长调节素/胰岛素样生长因子 (IGF) 水平。 Results are expressed in comparison with a pool of normal adult serum arbitrarily assigned a value of 1 U/ml.在 37 名未经治疗的患者中，平均 IGF 水平为 2.64 ± 0.13 (SEM) U/ml，而在 34 名正常受试者中，平均 IGF 水平为 1.06 ± 0.03 U/ml。在所有患者中，IGF 水平均高于对照值的平均值 + 2 SD。在治疗后研究的患者中，43名垂体瘤完全切除的患者中，三分之二的IGF水平正常或低于正常，而其余三分之一的值高于正常值，而34名垂体瘤未完全切除的患者的IGF值接近未治疗患者的IGF值。在这些受试者中，钴疗法降低了 IGF 水平，但 IGF 水平仍然较高......
Serum somatomedin/insulin-like growth factor (IGF) levels in 92 acromegalic patients were measured, after gel filtration in acetic acid, by means of a competitive proteinbinding assay using specific binding proteins produced by rat liver in culture and human IGF-I as tracer. Results are expressed in comparison with a pool of normal adult serum arbitrarily assigned a value of 1 U/ml. In 37 untreated patients, the mean IGF level was 2.64 ± 0.13 (SEM) U/ml, whereas in 34 normal subjects, it was 1.06 ± 0.03 U/ml. In all patients, IGF levels were above the mean + 2 SD of control values. Among the patients studied after treatment, two thirds of the 43 patients in whom removal of the pituitary tumor was complete had normal or subnormal IGF levels, while the remaining third had values above normal, and 34 patients in whom removal of the pituitary tumor was incomplete had IGF values close to those in untreated patients. In these subjects, cobalt therapy reduced the IGF levels, which, nevertheless, remained higher ...