Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain.
Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain.
复制标题
胰岛素样生长因子：通过大脑在生长激素负反馈和体重调节中发挥作用。
作者：
G. Tannenbaum;H. Guyda;B. Posner
ILA是一种富含胰岛素样生长因子的制剂，脑室内给药可导致生长激素分泌事件和体重显著减少，并与24小时内食物摄入量减少有关。中心注射胰岛素和牛血清白蛋白则无此作用。这些发现表明，胰岛素样生长因子在中枢神经系统水平上在生长激素负反馈和体重调节中发挥作用。
Intracerebroventricular administration of ILA's, a preparation enriched in insulin-like growth factors, caused a marked decrease in growth hormone secretory episodes and in body weight associated with reduced food intake over 24 hours. Central injection of insulin and bovine serum albumin had no such effects. These findings suggest that insulin-like growth factors play a role in growth hormone negative feedback and body weight regulation at the level of the central nervous system.
影响因子：
56.9
作者：
BERELOWITZ, M;SZABO, M;HINTZ, RL
通讯作者：
HINTZ, RL