Mechanical signals modulated vascular endothelial growth factor-A (VEGF-A) alternative splicing in osteoblastic cells through actin polymerisation
Mechanical signals modulated vascular endothelial growth factor-A (VEGF-A) alternative splicing in osteoblastic cells through actin polymerisation
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DOI：
10.1016/j.bone.2008.02.011
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发表时间：
2008-06-01
期刊：
影响因子：
4.1
通讯作者：
Guignandon, Alain
中科院分区：
文献类型：
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作者：
Faure, Celine;Linossier, Marie-Therese;Guignandon, Alain
由于VEGF-A参与机械诱导的骨获得，并且由于VEGF以6种亚型存在，发挥各种生物学作用，因此我们研究了4种机械方案下成骨细胞（大鼠Ros 17/2.8和人成骨细胞）中VEGF亚型表达和VEGF蛋白质产生。机械方案（1%拉伸变形）设计为在不同频率（0.05至5 Hz）下输送固定循环次数（450）。我们发现负相关（R-2=0.76，p
Since VEGF-A is involved in mechanically induced bone gain and because vegf exists under 6 isoforms exerting various biological effects, we studied vegf isoform expression and VEGF protein production in osteoblastic cells (rat Ros17/2.8 and human osteoblasts) submitted to 4 mechanical regimens. Mechanical regimens (1% stretch deformation) were designed with a fixed number of cycles (450) delivered at various frequencies (0.05 to 5 Hz). We found a negative correlation (R-2=0.76, p