Rh(III)-Catalyzed [4+1]-Annulation of Azoxy Compounds with Alkynes: A Regioselective Approach to 2H-Indazoles
Rh(III)-Catalyzed [4+1]-Annulation of Azoxy Compounds with Alkynes: A Regioselective Approach to 2H-Indazoles
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Rh(III)-催化氧化偶氮化合物与炔烃的[4 1]-环化：2H-吲唑的区域选择性方法
DOI：
10.1021/acs.orglett.7b00982
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发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
You Jingsong
中科院分区：
文献类型：
--
作者：
Long Zhen;Yang Yudong;You Jingsong
铑催化的氧化偶氮化合物与炔的区域选择性 C-H 活化/环化已被公开，可构建多种 2H-吲唑。在环化捕获过程中观察到[4 + 1]-环加成而不是正常的[4 + 2]模式以及氧原子转移和CC三键断裂。该方案具有广泛的底物范围、良好的官能团耐受性和独特的区域选择性。
A rhodium-catalyzed regioselective C–H activation/cyclization of azoxy compounds with alkynes has been disclosed to construct a variety of 2H-indazoles. A [4 + 1]-cycloaddition rather than a normal [4 + 2] mode is observed in the process of cyclative capture along with an oxygen-atom transfer and a CC triple bond cleavage. This protocol features a broad substrate scope, a good functional group tolerance, and an exclusive regioselectivity.