SARS-CoV-2 can induce brain and spine demyelinating lesions
SARS-CoV-2 can induce brain and spine demyelinating lesions
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DOI：
10.1007/s00701-020-04374-x
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发表时间：
2020-05-04
影响因子：
2.4
通讯作者：
Fontanella, Marco Maria
中科院分区：
文献类型：
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作者：
Zanin, Luca;Saraceno, Giorgio;Fontanella, Marco Maria
SARS-CoV-2可以在感染的早期阶段攻击中枢神经系统。头痛、嗅觉障碍和感觉障碍是常见的症状。如果严重的新冠肺炎，意识障碍和癫痫可作为并发症发生。我们描述了一位新冠肺炎患者因间质性肺炎和癫痫而入院的病例。MRI显示新诊断的脱髓鞘病变。大剂量类固醇治疗使神经和呼吸得到恢复。我们推测是SARS-CoV-2诱导的一种延迟免疫反应。该病毒可能导致SIRS样免疫紊乱或起到感染性触发作用。应及时采取侵入性治疗，避免缺氧性神经毒性，预防中枢神经系统损伤。
SARS-CoV-2 can attack the central nervous system in the early stages of infection. Headache, anosmia, and dysgeusia are common symptoms. Disturbance of consciousness and seizures can occur as complications in case of severe COVID-19. We described the case of a COVID-19 patient admitted for interstitial pneumonia and seizures. MRI showed newly diagnosed demyelinating lesions. High-dose steroid treatment allowed neurological and respiratory recovery. We speculated a delayed immune response induced by SARS-CoV-2. The virus may lead to a SIRS-like immune disorder or play a role of infective trigger. Prompt invasive treatment should be adopted to avoid hypoxic neurotoxicity and prevent CNS injuries.