Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
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DOI：
10.1038/nn1058
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发表时间：
2003-06-01
影响因子：
25
通讯作者：
Lüthi, A
中科院分区：
文献类型：
--
作者：
Bissière, S;Humeau, Y;Lüthi, A
恐惧条件反射涉及外侧杏仁核兴奋性突触传递的长时程增强（LTP）的诱导，外侧杏仁核是一种受GABA能抑制严格控制的脑结构。在这里，我们表明，多巴胺门在小鼠杏仁外侧核的LTP的诱导抑制前馈抑制当地interneurons。我们的研究结果提供了一个细胞机制的多巴胺能调制的恐惧条件反射，并指出，前馈抑制的抑制代表了一个关键的机制，在外侧杏仁核的诱导联合突触可塑性。
Fear conditioning involves the induction of long-term potentiation (LTP) of excitatory synaptic transmission in the lateral amygdala, a brain structure which is tightly controlled by GABAergic inhibition. Here we show that dopamine gates the induction of LTP in the mouse lateral amygdala by suppressing feedforward inhibition from local interneurons. Our findings provide a cellular mechanism for the dopaminergic modulation of fear conditioning and indicate that suppression of feedforward inhibition represents a key mechanism for the induction of associative synaptic plasticity in the lateral amygdala.