Interaction between interstitial cells and smooth muscles in the lower urinary tract and penis
Interaction between interstitial cells and smooth muscles in the lower urinary tract and penis
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DOI：
10.1113/jphysiol.2006.116632
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发表时间：
2006-11-01
影响因子：
5.5
通讯作者：
Hashitani, Hikaru
中科院分区：
文献类型：
--
作者：
Hashitani, Hikaru
下尿路和下体组织的平滑肌表现出自发的收缩活动，这种收缩活动依赖于L钙通道。这种活动的机制是自发的电活动，在这些组织之间表现出不同的形式和性质。最近的研究表明，间质细胞广泛分布于泌尿生殖系统，并提示它们参与自发的肌肉活动。该系统中的ICs不是肠道中充当电起搏器的Cajal间质细胞(ICC)的简单类比，而是代表组织之间的差异，这可能解释了每个器官的个别特征。在膀胱和躯体组织中，平滑肌细胞能够产生自发的电活动，ICs可能调节平滑肌的活动。小体组织中的ICS通过环氧合酶-2(COX-2)活性释放前列腺素，不仅增强自发的，也增强神经介导的α-肾上腺素能收缩。在膀胱中，它们在不同细胞群之间信号整合中的基本作用已被提出，因此ICs的变化可能导致膀胱过度活动，这是一种由逼尿肌平滑肌兴奋性增加引起的病理状况。在尿路中，ICs和ICC一样可以起到电子起搏器的作用。然而，尿道平滑肌的整体收缩能力并不一定依赖于ICs的起搏，因此一些平滑肌群体可能也有自己的兴奋性。
Smooth muscles in the lower urinary tract and corporal tissue exhibit spontaneous contractile activity which depends on L-type Ca2+ channels. The mechanism underlying this activity is spontaneous electrical activity which shows varied form and property between these tissues. Recent studies revealed that interstitial cells (ICs) are widely distributed in the genitourinary system, and suggested their involvement in spontaneous muscle activity. ICs in the system are not a simple analogy of interstitial cells of Cajal (ICC) in the gut, which act as electrical pacemaker, but represent variability amongst tissues which may account for individual characteristics of each organ. In the bladder and corporal tissue, where smooth muscle cells are capable of generating spontaneous electrical activity, ICs may modulate smooth muscle activity. ICs in corporal tissue release prostaglandins via cyclooxygenase-2 (COX-2) activity and reinforce not only spontaneous but also nerve-mediated alpha-adrenergic contractions. In the bladder, their fundamental role in the integration of signals between populations of cells has been proposed, and thus changes in ICs may contribute to an overactive bladder, a pathological condition which results from increased excitability in detrusor smooth muscles. In the urethra, ICs may act as electrical pacemakers as do ICC. However, overall contractility of urethral smooth muscles does not necessarily rely on pacemaking of ICs, and thus some population of smooth muscles may also have their own excitability.