A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men
A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men
复制标题
DOI：
10.1016/s0021-9150(01)00673-6
复制
发表时间：
2002-04-01
期刊：
影响因子：
5.3
通讯作者：
Ridker, PM
中科院分区：
文献类型：
--
作者：
Liu, S;Schmitz, C;Ridker, PM
背景资料：编码胆固醇酯转运蛋白（CETP）的基因的分子变异，如Taq 1B多态性与较高的血浆高密度脂蛋白（HDL）浓度相关。然而，这种多态性是否与心肌梗死（MI）的风险是不确定的。方法与结果：在一项纳入14916名健康男性的前瞻性队列研究中，在384名随后发生首次MI的参与者（病例）和相同数量的年龄和吸烟匹配的参与者（对照组）中确定CETP基因Taq 1B多态性的等位基因状态，这些参与者在随访期间没有心血管疾病。总体而言，B2 B2基因型存在于17%的研究参与者中，并与较高的HDL胆固醇水平（平均mg/dl [ +/- S.D.]，B1 B1基因型为45 +/- 11，B1 B2基因型为48 +/- 13，B2 B2基因型为50 +/- 12; P = 0.01）。然而，在这三种基因型之间，发生心肌梗死的风险没有显著差异。校正冠状动脉危险因素（但不包括高密度脂蛋白）后，与B1 B1基因型相比，B1 B2基因型和B2 B2基因型未来心肌梗死的相对风险分别为1.12（95%CI 0.74 - 1.70）和0.95（95%CI 0.54-1.66）。在低HDL水平个体的亚组分析中，B2 B2基因型似乎比B1 B1：基因型具有更低的MI风险。然而，高HDL参与者发生MI的风险较低，无论其CETP基因型如何。结论：在这项对表面健康的美国中年男性的前瞻性研究中，CETP基因中Taq 1B等位基因B2的携带者具有较高的HDL浓度，但并没有降低MI的风险。浓缩摘要：在一组表面健康的美国中年男性中，CETP基因型与MI风险之间的关系在巢式病例对照研究中进行了前瞻性研究。校正冠状动脉危险因素（但不包括高密度脂蛋白）后，不同基因型的9年发生心肌梗死的风险没有显著差异。与B1 B1基因型相比，B1 B2基因型和B2 B2基因型未来MI的相对风险分别为1.12（95% CI 0.74 - 1.70）和0.95（95% CI 0.54-1.66），（C）2002 Elsevier Science爱尔兰Ltd.版权所有。
Background: Molecular variations in the gene coding for the cholesteryl ester transfer protein (CETP) such as the Taq1B polymorphism are associated with higher plasma high-density lipoprotein (HDL) concentration. However, whether this polymorphism is associated with risk of myocardial infarction (MI) is uncertain. Methods and results: In a prospective cohort of 14916 apparently healthy men enrolled in the Physicians' Health Study, allelic status for the Taq1B polymorphism in the CETP gene was determined among 384 participants who subsequently developed a first MI (cases) and among an equal number of age and smoking-matched participants who remained free of cardiovascular disease during follow-up (controls). Overall, the B2B2 genotype was present in 17% of the study participants and was associated with higher HDL cholesterol levels (mean mg/dl [ +/- S.D.], 45 +/- 11 for the B1B1 genotype, 48 +/- 13 for the B1B2 genotype and 50 +/- 12 for the B2B2 genotype; P = 0.01). However, the risk of developing MI did not differ significantly across these three genotypes. After adjustment for coronary risk factors (but not HDL), the relative risks for future MI were 1.12(95% CI 0.74 - 1.70) for the B1B2 genotype and 0.95(95% CI 0.54-1.66) for the B2B2 genotype, compared with the B1B1 genotype. In subgroup analysis of individuals with low HDL levels, B2B2 genotype appeared to have a lower risk of MI compared with the B1B1:genotype. However, participants with high HDL were at lower risk of developing MI regardless of their CETP genotype. Conclusions: In this prospective study of apparently healthy middle-aged US men, carriers of the B2 allele of the Taq1B in the CETP gene had higher HDL concentrations, but did not have lower risk of MI. Condensed abstract: In a cohort of apparently healthy middle-aged US men, the relation between CETP genotype and MI risk was prospectively examined in a nested case-control study. After adjusting for coronary risk factors (but not HDL), the 9-year risk of developing MI did not differ significantly by genotype. Comparing to the B1B1 genotype, the relative risks for future MI were 1.12 (95% CI 0.74 - 1.70) for the B1B2 genotype and 0.95 (95% CI 0.54-1.66) for the B2B2 genotype, (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.