Circannual rhythms of systolic and diastolic blood pressure in relation to plasma aldosterone and urinary norepinephrine in elderly subjects and in children.
Circannual rhythms of systolic and diastolic blood pressure in relation to plasma aldosterone and urinary norepinephrine in elderly subjects and in children.
复制标题
老年受试者和儿童收缩压和舒张压的昼夜节律与血浆醛固酮和尿去甲肾上腺素的关系。
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
E. Petrescu
中科院分区：
文献类型：
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作者：
Nicolau Gy;Erhard Haus;C. Bogdan;L. Plîngă;E. Robu;E. Ungureanu;L. Sackett;E. Petrescu
66名老年男性和87名老年女性77 +/- 8（S.D.）在285个分布图中研究了30岁的受试者，所述分布图包括在受试者清醒时间内以4小时间隔获得的收缩压和舒张压的测量，持续2天或7天，以及（其中）在一个24小时跨度内以4小时间隔在6个样品中收集的血浆醛固酮和尿去甲肾上腺素的测定。这些资料分布在四季。用单余弦法计算各剖面的昼夜平均值，用宾汉检验和方差分析分析其年变化。收缩压和舒张压呈年周期性变化，收缩压峰值出现在春季，舒张压峰值出现在夏季。尿去甲肾上腺素的年周期节律仅在冬季达到峰值的妇女中有统计学意义，与血压的年周期节律不同步。在血浆醛固酮中，发现最高值在秋季和冬季，仅在女性中达到P <0.05的统计学显著性水平。与老年受试者相比，87名男孩和107名女孩为11 +/- 1.5（SD）用同样的方法研究了24小时内四个季节的100岁儿童的收缩压、舒张压和去甲肾上腺素分泌的年周期节律，在冬季达到高峰。发现儿童血浆醛固酮浓度的昼夜节律在秋季最高值和春季最低值（当血压值也是最低的）。考虑到所有关于节律之间可能的因果关系的资格，显示出一致性或相位差异，似乎儿童和老年受试者之间的心血管和相关内分泌功能的跨年度时间结构存在某些差异，这可能具有临床意义。
Sixty six elderly men and 87 elderly women 77 +/- 8 (S.D.) years of age were studied in 285 profiles consisting of measurements of systolic and diastolic blood pressure obtained at 4 hour intervals during the waking hours of the subjects for 2 or 7 days and (among others) plasma aldosterone and urinary norepinephrine determinations collected in six samples at 4 hour intervals during one 24-hour span. The profiles were spread through all four seasons. The circadian means were calculated for each profile by the single cosinor method and the circannual variations were analyzed by the Bingham test and analysis of variance. A circannual rhythm of the systolic and the diastolic blood pressure was found with a peak systolic pressure in spring and peak diastolic pressure in summer. A circannual rhythm in urinary norepinephrine was statistically significant only in the women with a peak in winter, out of phase with the circannual rhythm in blood pressure. In plasma aldosterone, the highest values were found during fall and winter with statistical significance reached at the p less than .05 level in the women only. In contrast to the elderly subjects, 87 boys and 107 girls 11 +/- 1.5 (S.D.) years of age studied by the same methodology over one 24-hour span each spread throughout the four seasons showed a circannual rhythm in systolic and diastolic blood pressure and in norepinephrine excretion with a peak during winter. A circannual rhythm of the circadian mesor of the plasma aldosterone concentration was found in the children with highest values in fall and lowest values in spring (when the blood pressure values also were lowest). With all qualifications in mind about possible causal relations between rhythms showing a coincidence or a difference in phase, it appears that there are certain differences in the circannual time structure of cardiovascular and related endocrine functions between children and elderly subjects which may be of clinical importance.