Structural control of self-assembled nanofibers by artificial β-sheet peptides composed of D- or L-isomer
Structural control of self-assembled nanofibers by artificial β-sheet peptides composed of D- or L-isomer
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DOI：
10.1021/ja0558387
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发表时间：
2005-12-21
影响因子：
15
通讯作者：
Higashi, N
中科院分区：
文献类型：
--
作者：
Koga, T;Matsuoka, M;Higashi, N
以人工合成的由1-D-氨基酸组成的三嵌段β折叠肽1D和1D为结构单元，发展了一种新的控制肽自组装的方法。在适当的条件下，多肽1D和1D分别自组装成左旋和右旋的β-折叠纳米纤维。而1 L/1D二元混合物在相同条件下只能形成球状聚集体。因此，淀粉样蛋白的形成和它的纳米结构可以成功地调节组成肽种类的立体特异性。
A novel method for the control of peptide self-assembly has been developed by using synthetic triblock-type β-sheet peptides composed ofl- ord-amino acid,1Land1D, as building blocks. The peptides1Land1Dself-assemble into β-sheet nanofibers with left- and right-handed twists, respectively, under appropriate condition. On the other hand, the1L/1Dbinary mixture was found to form only globular aggregates at the same condition. Thus, amyloid-like nanofiber formation and its nanostructure could be successfully regulated by the stereospecificity of the constituent peptide species.