Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters - The Rotterdam Study
Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters - The Rotterdam Study
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DOI：
10.1016/j.ophtha.2007.06.036
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发表时间：
2008-05-01
期刊：
影响因子：
13.7
通讯作者：
Breteler, Monique M. B.
中科院分区：
文献类型：
--
作者：
De Jong, Frank Jan;Vernooij, Meike W.;Breteler, Monique M. B.
目的：视网膜血管直径，特别是较大的微静脉直径，与脑血管疾病有关。视网膜微静脉直径增大可能反映脑缺血。作者调查了小动脉血氧饱和度（SaO（2））和脑血流量（CBF）（脑氧供应的指标）是否与视网膜小动脉或小静脉直径相关。设计：在基于人群的鹿特丹研究中进行的横断面研究。参与者：随机选择年龄在55岁或以上的参与者（n = 696），他们接受了眼部检查和脑部磁共振成像（MRI）。通过右食指脉搏血氧饱和度测定法测定小动脉血氧饱和度。脑血流量使用相衬MRI序列进行评估，测量基底动脉和颈内动脉的流量。测量脑体积以表示每100 ml脑体积的CBF。视网膜小动脉和小静脉直径的数字化眼底彩色荧光测量的每一个参与者的一只眼睛。回归模型用于研究SaO（2）和CBF与视网膜血管直径的关系。主要结果测量：平均视网膜小动脉和小静脉直径（以微米为单位）。SaO（2）小于96%的患者（n 113）与SaO（2）大于96%的患者（n = 583;年龄和性别校正的平均差异，5.6 μ m; 95%置信区间，1.2-10.0）相比，平均小静脉直径大5 μ m。单独分析时，脑血流量与微静脉直径无关。其他分析显示SaO（2）和小静脉增宽之间的关联仅限于CBF最低三分位数的参与者。SaO（2）和CBF与小动脉直径之间无相关性。对已建立的心血管危险因素进行额外的调整并没有改变结果。结论：观察到较低的SaO（2）与较大的视网膜小静脉直径相关，特别是在存在较低的CBF时。这些发现表明，微静脉增宽可能反映了较低的氧气供应，特别是大脑。
Objective: Retinal vessel diameters, in particular larger venular diameters, have been associated with cerebrovascular disease. Larger retinal venular diameters may reflect cerebral ischemia. The authors investigated whether arteriolar oxygen saturation (SaO(2)) and total cerebral blood flow (CBF), indicators of cerebral oxygen supply, are associated with retinal arteriolar or venular diameters.Design: Cross-sectional study performed within the population-based Rotterdam Study.Participants: Randomly selected participants aged 55 years or older (n = 696), who underwent both an eye examination and brain magnetic resonance imaging (MRI).Methods: Arteriolar oxygen saturation was determined by pulse oximetry on the right index finger. Cerebral blood flow was assessed using a phase-contrast MRI sequence that measured the flow in the basilar and both internal carotid arteries. Brain volume was measured to express CBF per 100 ml brain volume. Retinal arteriolar and venular diameters were measured on digitized fundus color transparencies on 1 eye of each participant. Regression models were used to investigate the association of SaO(2) and CBF with retinal vessel diameters.Main Outcome Measures: Mean retinal arteriolar and venular diameters (in micrometers).Results: Lower SaO(2) was associated with larger venular diameters. Persons with SaO(2) less than 96% (n 113) had on average 5 mu m larger venular diameters compared with those with SaO(2) of 96% or more (n = 583; age- and gender-adjusted mean difference, 5.6 mu m; 95% confidence interval, 1.2-10.0). Cerebral blood flow was not related to venular diameters when analyzed separately. Additional analyses showed that the association between SaO(2) and venular widening was confined to participants within the lowest tertile of CBF. No associations were found between SaO(2) or CBF and arteriolar diameters. Additional adjustment for established cardiovascular risk factors did not change the results.Conclusions: An association of lower SaO(2) with larger retinal venular diameters was observed, in particular in the presence of lower CBF. These findings suggest that venular widening may reflect a lower oxygen supply, especially to the brain.