Insulin-Like Growth Factor-I is a Marker for the Nutritional State.
Insulin-Like Growth Factor-I is a Marker for the Nutritional State.
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发表时间：
2015-12
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通讯作者：
C. Hawkes;A. Grimberg
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作者：
C. Hawkes;A. Grimberg
血清胰岛素样生长因子-I(IGF一L)水平的测定通常被用来筛查身材矮小的儿童和青少年生长激素(GH)/胰岛素样生长因子-I轴的紊乱。IGF-I浓度对营养状态的短期和长期变化很敏感，对IGF-I测量的解释需要了解儿童的营养状况。在这篇综述中，我们总结了营养对生长激素/胰岛素样生长因子-I轴的影响，并回顾了这些相互作用在整个儿童时期的临床意义，包括营养不良和营养过剩。
Measurement of the serum concentration of insulin-like growth factor-I (IGF-l) is generally used as a screening investigation for disorders of the growth hormone (GH)/IGF-I axis in children and adolescents with short stature. IGF-I concentration is sensitive to short-term and chronic alterations in the nutritional state, and the interpretation of IGF-I measurements requires knowledge of the child's nutritional status. In this review, we summarize the effects of nutrition on the GH/IGF-I axis, and review the clinical implications of these interactions throughout childhood, both in under-nutrition and over-nutrition.