Neuroprotective effects of pretreatment of ginsenoside Rb1 on severe cerebral ischemia-induced injuries in aged mice: Involvement of anti-oxidant signaling
Neuroprotective effects of pretreatment of ginsenoside Rb1 on severe cerebral ischemia-induced injuries in aged mice: Involvement of anti-oxidant signaling
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DOI：
10.1111/ggi.12699
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发表时间：
2017-02-01
影响因子：
3.3
通讯作者：
Yang, Yanbei
中科院分区：
文献类型：
--
作者：
Dong, Xiao;Zheng, Lei;Yang, Yanbei
目的人参皂甙是人参中草药的一种化合物，具有抗氧化、抗炎等作用，对脑缺血后的脑损伤具有治疗作用。在老年人群中，衰老诱导的氧化应激与脑损伤的恶化有关，这也可能通过抗氧化剂（如黄芪皂苷）得到改善。然而，这一假说还有待探讨。MethodsHere，我们提出了体内研究强调的保护功能，天然甾体苷衍生物，从人参皂苷纯化，在神经损伤的老化过程中。结果与年轻的小鼠相比，大脑中动脉闭塞后的脑损伤的恢复显着受损，而长期口服抗肿瘤Rb 1可明显预防损伤，且呈剂量依赖性。此外，我们还进一步探讨了脑缺血对老年小鼠氧化应激和细胞外信号调节激酶激活的影响，并发现这两种作用均被抗氧化剂Rb 1所阻断。结论抗氧化剂Rb 1可能作为抗衰老药物用于治疗老年患者的神经系统疾病，如脑卒中。Geriatr Gerontol Int 2017; 17：338-345。
AimGinsenosides, a class of ginseng compounds of herbal medicine, have been shown to have therapeutic potential for the neuroprotection of brain damage after cerebral ischemia because of their activities including anti-oxidant and anti-inflammation. In the elderly population, aging-induced oxidative stress has been implicated in exacerbating brain injury, which might also be ameliorated by anti-oxidants, such as ginsenosides. However, this hypothesis has yet to be explored.MethodsHere we present invivo studies highlighting a protective function of ginsenoside Rb1, a natural steroid glycoside derivative purified from saponin of Panax ginseng, in neurological injury during aging.ResultsCompared with young mice, the recovery of brain damage after middle cerebral artery occlusion is significantly impaired in aged mice, whereas the long-term pretreatment with ginsenoside Rb1 through oral administration can greatly prevent the injury in a dose-dependent manner. In addition, we further explored the involvement of oxidative stress and extracellular signal-regulated kinase activation in aged mice stimulated by cerebral ischemia, both of which were found to be blocked by ginsenoside Rb1.ConclusionsThese observations suggest that ginsenoside Rb1 could represent promising applications as anti-oxidants for the anti-aging treatment of neurological disorders, such as stroke, in elderly patients. Geriatr Gerontol Int 2017; 17: 338-345.