Impaired interhemispheric connectivity in medication-naive patients with major depressive disorder.
Impaired interhemispheric connectivity in medication-naive patients with major depressive disorder.
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DOI：
10.1503/jpn.110132
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Ke Xu;Wenyan Jiang;Ling Ren;Ouyang Xuan;Yifeng Jiang;Feng Wu;Ling-tao Kong;F. Womer;Zhening Liu;H. Blumberg;Yanqing Tang;Fei Wang
中科院分区：
文献类型：
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作者：
Ke Xu;Wenyan Jiang;Ling Ren;Ouyang Xuan;Yifeng Jiang;Feng Wu;Ling-tao Kong;F. Womer;Zhening Liu;H. Blumberg;Yanqing Tang;Fei Wang
BACKGROUND Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in major depressive disorder (MDD). The purpose of this study was to investigate interhemispheric connectivity in medication-naive patients with MDD by measuring fractional anisotropy in the CC with diffusion tensor imaging (DTI) techniques. METHODS We obtained DTI scans from medication-naive patients with MDD and from matched healthy controls. Fractional anisotropy values were compared using semiautomatic region of interest methods to localize the regional CC differences between these 2 groups. RESULTS We enrolled 27 patients and 27 controls in our study. Fractional anisotropy values were significantly lower in the anterior genu of the CC in the MDD group than in the control group (p = 0.009, corrected); results were not significantly different in any other CC subregions. LIMITATIONS As patients with MDD were already experiencing acute episodes, future studies of individuals at risk for MDD are warranted to elucidate the interhemispheric connectivity abnormalities associated with the predisposition to MDD. CONCLUSION The findings demonstrate abnormalities in the structural integrity of the anterior genu of the CC in medication-naive individuals with MDD, which may contribute to impairment of interhemispheric connectivity in patients with this disorder.
