In vivo support for the new concept of pulmonary blood flow-mediated CO2 gas excretion in the lungs
In vivo support for the new concept of pulmonary blood flow-mediated CO2 gas excretion in the lungs
复制标题
肺血流介导的肺部二氧化碳气体排泄新概念的体内支持
DOI：
10.1152/ajplung.00205.2014
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
and Ohhashi T
中科院分区：
文献类型：
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作者：
Kawai Y;Ajima K;Kaidoh M;Sakaguchi M;Tanaka S;Kawamata M;Kimura H;and Ohhashi T
为了进一步检验肺血流依赖性CO2气体排泄概念的有效性，我们研究了纵隔内球囊导管插入术、肺动脉导管插入术或异丙肾上腺素（ISP）诱导的肺血流变化对呼气末CO2气体压力（PeCO 2）、肺动脉最大流速（Max Vp）、全身动脉压、和麻醉家兔的心率。我们还评估了在贫血或肺栓塞的临床模型中PeCO 2的变化。PeCO 2与最大Vp之间几乎呈线性关系。在一项小肺动脉狭窄的实验中，PeCO 2迅速下降，下降的速度取决于狭窄的程度。ISP使麻醉家兔的PeCO_2显著增加。相反地，用Piceatannol或乙酰唑胺治疗诱导PeCO 2显著降低。用细胞表面F1/FOATP合酶抗体处理引起PeCO 2本身的显著减少和ISP诱导的PeCO 2增加。显著贫血[%红细胞压积（Ht），70 ± 47%]对PeCO 2和SAP均无显著影响。另一方面，在存在不太严重的贫血时（%Ht：100 ~ 70%），当兔的血液粘度降低时，PeCO 2和SAP均显著降低。诱导肺栓塞的家兔表现出显著降低的PeCO 2值，这与其最大Vp的降低相一致。总之，我们重申了所提出的肺中CO2气体交换概念的有效性。
To further examine the validity of the proposed concept of pulmonary blood flow-dependent CO2gas excretion in the lungs, we investigated the effects of intramediastinal balloon catheterization-, pulmonary artery catheterization-, or isoprenaline (ISP)-induced changes in pulmonary blood flow on the end-expiratory CO2gas pressure (PeCO2), the maximal velocity of the pulmonary artery (Max Vp), systemic arterial pressure, and heart rate of anesthetized rabbits. We also evaluated the changes in the PeCO2in clinical models of anemia or pulmonary embolism. An almost linear relationship was detected between the PeCO2and Max Vp. In an experiment in which small pulmonary arteries were subjected to stenosis, the PeCO2fell rapidly, and the speed of the reduction was dependent on the degree of stenosis. ISP produced significant increases in the PeCO2of the anesthetized rabbits. Conversely, treatment with piceatannol or acetazolamide induced significant reductions in the PeCO2. Treatment with a cell surface F1/FOATP synthase antibody caused significant reductions in the PeCO2itself and the ISP-induced increase in the PeCO2. Neither the PeCO2nor SAP was significantly influenced by marked anemia [%hematocrit (Ht), 70∼47%]. On the other hand, in the presence of less severe anemia (%Ht: 100∼70%) both the PeCO2and SAP fell significantly when the rabbits' blood viscosity was decreased. The rabbits in which pulmonary embolisms were induced demonstrated significantly reduced PeCO2values, which was compatible with the lowering of their Max Vp. In conclusion, we reaffirm the validity of the proposed concept of CO2gas exchange in the lungs.