Age-related changes of calcitonin secretion in females.
Age-related changes of calcitonin secretion in females.
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女性降钙素分泌的年龄相关变化。
DOI：
10.1210/jcem-50-3-437
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
L. J. Defto
中科院分区：
文献类型：
--
作者：
I. Shamonki;A. Frumar;I. Tataryn;D. Meldrum;B. Davidson;J. Parthemore;H. Judd;L. J. Defto
研究了50例20 ~ 69岁正常女性降钙素分泌情况，每10年10例。在以3mg /kg体重输注钙（作为氯盐）10分钟的反应期间，通过RIA测量激素。随着年龄的增长，钙刺激的血浆降钙素逐渐降低。线性回归分析显示，降钙素反应与年龄呈显著负相关（P < 0.05） （r = 0.29）。绝经后女性的降钙素反应明显小于绝经前女性（P < 0.01）。降钙素最大反应时间从年轻受试者的10分钟逐渐转变为老年受试者的20分钟。这些研究表明，女性的降钙素分泌随着年龄的增长而减少。这种减少可能在女性随着年龄增长而发生的骨量逐渐减少的发病机制中起一定作用。
Calcitonin secretion was studied in 50 normal females from 20--69 yr of age, with 10 subjects in each decade. Hormone measurements were made by RIA during response to a 10-min infusion of calcium (as the chloride salt) at 3 mg/kg BW. There was a progressive decrease of the calcium-stimulated plasma calcitonin with age. Linear regression analysis demonstrated a significant (P less than 0.05) negative correlation (r = 0.29) between calcitonin response and age. Postmenopausal females had a significantly (P less than 0.01) smaller calcitonin response than premenopausal females. The time of maximum calcitonin response progressively shifted from 10 min in the younger subjects to 20 min in the older subjects. These studies demonstrated that calcitonin secretion decreases with age in females. This decrease may play some role in the pathogenesis of the progressive loss of bone mass which occurs with aging in females.