Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish.
Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish.
复制标题
在斑马鱼中对胰腺内分泌细胞适应和糖尿病进行建模。
DOI：
10.3389/fendo.2017.00009
复制
发表时间：
2017
影响因子：
5.2
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Maddison LA;Chen W
葡萄糖稳态是能量平衡的重要元素，并且在从果蝇到哺乳动物的生物体中是保守的。控制脊椎动物循环葡萄糖水平的核心是胰腺的内分泌细胞，特别是产生胰岛素的β细胞和产生胰高血糖素的α细胞。α-和β-细胞的一个特征是它们的可塑性，即在功能和数量上适应激素需求增加的生理和病理生理条件的能力。这些维持葡萄糖稳态的适应性反应的分子机制尚未完全确定。斑马鱼是一个有吸引力的模型，由于低成本，高繁殖力，和顺从性的遗传和化合物筛选，和机制的胰腺内分泌细胞的发展是保守的斑马鱼和哺乳动物之间。发育后，斑马鱼的β-和α-细胞都显示出与哺乳动物一样的可塑性。本文就斑马鱼胰腺内分泌细胞适应性的研究进展作一综述。我们进一步探索了斑马鱼作为糖尿病模型的实用性，这是一个考虑到人类糖尿病增加的相关主题。
Glucose homeostasis is an important element of energy balance and is conserved in organisms from fruit fly to mammals. Central to the control of circulating glucose levels in vertebrates are the endocrine cells of the pancreas, particularly the insulin-producing β-cells and the glucagon producing α-cells. A feature of α- and β-cells is their plasticity, an ability to adapt, in function and number as a response to physiological and pathophysiological conditions of increased hormone demand. The molecular mechanisms underlying these adaptive responses that maintain glucose homeostasis are incompletely defined. The zebrafish is an attractive model due to the low cost, high fecundity, and amenability to genetic and compound screens, and mechanisms governing the development of the pancreatic endocrine cells are conserved between zebrafish and mammals. Post development, both β- and α-cells of zebrafish display plasticity as in mammals. Here, we summarize the studies of pancreatic endocrine cell adaptation in zebrafish. We further explore the utility of the zebrafish as a model for diabetes, a relevant topic considering the increase in diabetes in the human population.