Effect of Coffee and Green Tea Consumption on the Risk of Liver Cancer: Cohort Analysis by Hepatitis Virus Infection Status
Effect of Coffee and Green Tea Consumption on the Risk of Liver Cancer: Cohort Analysis by Hepatitis Virus Infection Status
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DOI：
10.1158/1055-9965.epi-08-0923
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发表时间：
2009-06-01
影响因子：
3.8
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Inoue, Manami;Kurahashi, Norie;Tsugane, Shoichiro
尽管具有抗癌潜力，但考虑到丙型肝炎（HCV）和B病毒（HBV）感染，咖啡和绿色茶消费对肝癌风险的影响尚未得到前瞻性澄清。我们在日本公共卫生中心前瞻性研究队列II中，通过肝炎病毒感染状态，研究了咖啡和绿色茶消费是否与肝癌风险降低相关。在1993年至1994年期间，共有18，815名年龄在40至69岁之间的受试者参加了问卷调查和健康检查调查，并在2006年之前对肝癌的发病率进行了随访。共记录了110例新的肝癌病例。使用考克斯比例风险模型计算咖啡和绿色茶消费类别的风险比。与几乎从不喝咖啡的人相比，所有受试者中咖啡摄入量增加与肝癌风险降低相关（风险比= 3杯/天; P趋势= 0.67，0.49，0.54和0.025）。在HCV和HBV感染者中观察到类似的风险趋势。相反，在所有受试者中，没有观察到绿色茶消费与肝癌风险之间的关联。我们的研究结果表明，无论HCV和HBV感染状况如何，喝咖啡都可以降低肝癌的风险，而绿色茶可能不会降低这种风险。（Cancer Epidemiol Biomarkers Prev 2009;48（6）：1746-53）
In spite of their anticarcinogenic potential, the effect of coffee and green tea consumption on the risk of liver cancer has not been clarified prospectively in consideration of hepatitis C (HCV) and B virus (HBV) infection. We examined whether coffee and green tea consumption was associated with a reduced risk of liver cancer by hepatitis virus infection status in the Japan Public Health Center-Based Prospective Study Cohort II. A total of 18,815 subjects ages 40 to 69 years participating in a questionnaire and health checkup survey in 1993 to 1994 were followed for the incidence of liver cancer through 2006. A total of 110 cases of liver cancer were newly documented. Hazard ratios for coffee and green tea consumption categories were calculated with a Cox proportional hazards model. Compared with almost never drinkers, increased coffee consumption was associated with a reduced risk of liver cancer in all subjects (hazard ratio for = 3 cups/d; P-trend = 0.67, 0.49, 0.54, and 0.025). A similar risk tendency was observed in those with either or both HCV and HBV infection. In contrast, no association was observed between green tea consumption and the risk of liver cancer in all subjects. Our results suggest that coffee consumption may reduce the risk of liver cancer regardless of HCV and HBV infection status, whereas green tea may not reduce this risk. (Cancer Epidemiol Biomarkers Prev 2009;48(6):1746-53)