Kaposi's sarcoma and its associated herpesvirus.
Kaposi's sarcoma and its associated herpesvirus.
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DOI：
10.1038/nrc2888
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Boshoff C
中科院分区：
文献类型：
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作者：
Mesri EA;Cesarman E;Boshoff C
卡波西肉瘤（KS）是HIV感染者中最常见的癌症。卡波西肉瘤相关疱疹病毒（KSHV;也称为人类疱疹病毒8（HHV 8））是这种肿瘤的感染性原因。在这篇综述中，我们描述了KS和KSHV的流行病学，以及KSHV可以诱导KS的显着机制，在过去的16年中已经获得的见解。KSHV潜伏转录物，例如潜伏相关核抗原（拉娜）、病毒细胞周期蛋白、病毒FLIP和病毒编码的微小RNA，驱动细胞增殖并防止细胞凋亡，而KSHV溶解蛋白，例如病毒G蛋白偶联受体、K1和病毒编码的细胞因子（病毒白细胞介素6和病毒趋化因子）通过称为旁分泌瘤形成的机制进一步促进独特的血管增生性和炎症性KS病变。
Kaposi’s sarcoma (KS) is the most common cancer in HIV-infected untreated individuals. Kaposi’s sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 (HHV8)) is the infectious cause of this neoplasm. In this Review we describe the epidemiology of KS and KSHV, and the insights into the remarkable mechanisms through which KSHV can induce KS that have been gained in the past 16 years. KSHV latent transcripts, such as latency-associated nuclear antigen (LANA), viral cyclin, viral FLIP and viral-encoded microRNAs, drive cell proliferation and prevent apoptosis, whereas KSHV lytic proteins, such as viral G protein-coupled receptor, K1 and virally encoded cytokines (viral interleukin-6 and viral chemokines) further contribute to the unique angioproliferative and inflammatory KS lesions through a mechanism called paracrine neoplasia.