The co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer.
The co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer.
复制标题
MMP-9和Tenascin-C的共表达与胰腺癌的进展和预后显着相关
DOI：
10.1186/s13000-015-0445-3
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发表时间：
2015-12-10
影响因子：
2.6
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Xu Y;Li Z;Jiang P;Wu G;Chen K;Zhang X;Li X
研究背景基质金属蛋白酶-9（MMP-9）和腱生蛋白-C（TN-C）参与多种肿瘤的转移。方法采用免疫组化方法检测103例胰腺癌组织中TN-C和MMP-9的表达，并进行统计学分析，探讨TN-C和MMP-9在胰腺癌中的表达与胰腺癌临床预后的关系。结果MMP-9和TN-C在胰腺癌组织中的表达均明显增高，MMP-9和TN-C在胰腺癌组织中的表达与胰腺癌的临床病理参数及生存期有关。MMP-9和TN-C的共表达。MMP-9和TN-C的表达与血管浸润、淋巴结转移、肝转移及TNM分期有关。MMP-9和TN-C的共同表达与胰腺癌的转移密切相关。MMP-9或TN-C的个体过度表达显著降低总生存率。MMP-9和TN-C共表达组总生存率最低。MMP-9和TN-C的共同表达是胰腺癌患者生存的独立预测因子。结论MMP-9和TN-C的共同表达与较差的预后相关，并且被发现是生存的独立预测因子。
BackgroundMatrix metalloproteinase-9 (MMP-9) and Tenascin-C (TN-C) have been shown to be involved in the metastasis of many tumors. The purpose of this study was to determine the relationship between the co-expression of these two molecules and the clinical prognosis of pancreatic cancer.MethodsWe investigated the expression of TN-C and MMP-9 in 103 pancreatic cancer tissues by immunohistochemistry and used statistical analyses to investigate the correlations of individual expression or co-expression of these two molecules with clinicopathological parameters and survival of pancreatic cancer.ResultsThe expression of MMP-9 and TN-C were increased in pancreatic cancer. The co-expression of MMP-9 and TN-C was also detected. The expression of MMP-9 and TN-C were correlated with vascular invasion, lymph node invasion, liver metastases and TNM stage. The co-expression of MMP-9 and TN-C was significantly related to the pancreatic cancer metastases. The individual overexpression of MMP-9 or TN-C significantly decreased the overall survival rates. The co-expression of MMP-9 and TN-C had the lowest overall survival rates. The co-expression of MMP-9 and TN-C was an independent predictor of survival for pancreatic cancer patients.ConclusionsCo-expression of MMP-9 and TN-C was associated with poorer prognosis and was found to be an independent predictor of survival.