Lambert-Eaton syndrome antibodies target multiple subunits of voltage-gated Ca2+ channels.
Lambert-Eaton syndrome antibodies target multiple subunits of voltage-gated Ca2+ channels.
复制标题
兰伯特-伊顿综合征抗体靶向电压门控 Ca2 通道的多个亚基。
DOI：
10.1002/mus.24295
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发表时间：
2015
期刊：
影响因子：
3.4
通讯作者：
Atchison,WilliamD
中科院分区：
文献类型：
--
作者：
Hajela,RavindraK;Huntoon,KristinM;Atchison,WilliamD
Introduction: Lambert–Eaton myasthenic syndrome (LEMS) is an autoimmune presynaptic neuromuscular disorder. Autoantibodies against subunits of voltage‐gated calcium channels (VGCCs) associated with acetylcholine release are thought to cause LEMS.Methods: HEK293 cells expressing specific individual recombinant subunits of α1A, α1B, α1C, and α1E; β3; and α2δ of human neuronal VGCCs were exposed to antibodies from 3 LEMS patients, 1 patient with small‐cell lung carcinoma, and 1 with myasthenia gravis.Results: All LEMS patient antibodies bound to cells containing any of the α1or β3subunits alone or combined with α2δ subunits, but not α2δ alone. Autoantibodies from the patient with small‐cell lung carcinoma but not the myasthenia gravis patient targeted the same VGCC subunits.Conclusions: Autoantibodies from LEMS patients bind directly to multiple VGCC α1subunits as well as the β3subunit. Thus, multiple components of the presynaptic VGCC complex are prospective targets for antibodies in LEMS. Muscle Nerve51: 176–184, 2015
