Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia
Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia
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DOI：
10.1210/jc.2002-021942
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发表时间：
2003-05-01
影响因子：
5.8
通讯作者：
Taketani, Y
中科院分区：
文献类型：
--
作者：
Koga, K;Osuga, Y;Taketani, Y
为了更深入地了解血管内皮生长因子（VEGF）的作用，一种假定的物质参与先兆子痫的发展，我们测量了可溶性VEGF受体-1（sVEGFR-1）的浓度，一种天然的VEGF拮抗剂，血清中有先兆子痫的妇女（n = 31）和没有先兆子痫的妇女（n = 52）。先兆子痫妇女血清中sVEGFR-1的浓度（中位数7791 pg/mL）比对照组（1132 pg/mL，p < 0.0001）高6倍。两组sVEGFR-1水平在分娩后均明显下降。非先兆子痫患者血清sVEGFR-1水平与孕周呈正相关（r = 0.570 p < 0.0001），而先兆子痫患者血清sVEGFR-1水平与孕周无相关性（r = -0.130 p = 0.476）。这些发现可能表明sVEGFR-1可能通过拮抗VEGF对胎盘血管形成和母体内皮细胞功能的作用参与先兆子痫的病理生理学。
Hoping to get more insight into a role of vascular endothelial growth factor (VEGF), a putative substance involved in the development of preeclampsia, we measured concentrations of soluble VEGF receptor-1 (sVEGFR-1), a natural antagonist of VEGF, in serum from women with (n = 31) and without (n = 52) preeclampsia. The concentrations of sVEGFR-1 in serum from women with preeclampsia (median 7791 pg/mL) were > 6-fold higher than those from control (1132 pg/mL, p < 0.0001). The levels of sVEGFR-1 decreased markedly after delivery in both groups. Serum sVEGFR-1 levels of non-preeclamptic women were positively correlated with gestational age(r = 0.570 p < 0.0001), whereas those of preeclamptic women exhibited no correlation with gestational age (r = -0.130 p = 0.476). These findings may point to an involvement of sVEGFR-1 in the pathophysiology of preeclampsia possibly by antagonizing of VEGF effects on the formation of placental vasculature and maternal endothelial cell function.