Medicinal flowers.: XV.: The structures of noroleanane- and oleanane-type triterpene oligoglycosides with gastroprotective and platelet aggregation activities from flower buds of Camellia japonica
Medicinal flowers.: XV.: The structures of noroleanane- and oleanane-type triterpene oligoglycosides with gastroprotective and platelet aggregation activities from flower buds of Camellia japonica
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DOI：
10.1248/cpb.55.606
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发表时间：
2007-04-01
影响因子：
1.7
通讯作者：
Matsuda, Hisashi
中科院分区：
文献类型：
--
作者：
Yoshikawa, Masayuki;Morikawa, Toshio;Matsuda, Hisashi
山茶花花蕾的甲醇提取物。对乙醇或消炎痛诱导的大鼠胃粘膜损伤表现出有效的抑制活性。通过生物活性导向分离，从甲醇提取物中分离得到28-降齐墩果烷型三萜低聚糖苷，山茶苷A、B和C，以及一种齐墩果烷型三萜低聚糖苷，山茶苷D，以及五种已知化合物。根据化学和物理化学证据确定了山茶苷的绝对立体结构，其中包括对去甲三萜苷元（山茶烯二醇和山茶二醇）的结构修正。主要的寡苷，山茶苷A和B，除了对乙醇或吲哚美辛诱导的大鼠胃粘膜损伤的胃保护作用外，还显示出血小板聚集活性。
The methanolic extract from the flowers buds of Camellia japonica L. (Theaceae) were found to exhibit potent inhibitory activities on ethanol- or indomethacin-induced gastric mucosal lesions in rats. Through bioassay-guided separation, 28-noroleanane-type triterpene oligoglycosides, camelliosides A, B, and C, and an oleanane-type triterpene oligoglycoside, camellioside D, were isolated from the methanolic extract together with five known compounds. The absolute stereostructures of camelliosides were determined on the basis of chemical and physicochemical evidence, which included the structure revision of the nortriterpene aglycons (camellenodiol and camelledionol). The principal oligoglycosides, camelliosides A and B, showed platelet aggregation activity in addition to the gastroprotective effects on ethanol- or indomethacin-induced gastric mucosal lesions in rats.