Changes in Choroidal Thickness follow the RNFL Changes in Leber's Hereditary Optic Neuropathy
Changes in Choroidal Thickness follow the RNFL Changes in Leber's Hereditary Optic Neuropathy
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DOI：
10.1038/srep37332
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发表时间：
2016-11-17
影响因子：
4.6
通讯作者：
Barboni, Piero
中科院分区：
文献类型：
--
作者：
Borrelli, Enrico;Triolo, Giacinto;Barboni, Piero
Leber遗传性视神经病变（LHON）的典型特征是急性期的血管改变。本研究的目的是评估脉络膜的变化发生在无症状，急性和慢性阶段的LHON。我们招募了49名LHON患者，19名显性视神经萎缩（DOA）患者和22名健康对照者。对所有受试者进行黄斑和视乳头周围区域的光谱域光学相干断层扫描（SD-OCT），以评估黄斑和视乳头周围脉络膜厚度和视网膜神经纤维层（RNFL）厚度。黄斑和视乳头周围脉络膜厚度在急性LHON阶段显著增加。相反，黄斑脉络膜厚度在慢性期显著降低。此外，慢性LHON和DOA的视乳头周围脉络膜厚度减少。RNFL和脉络膜具有相同的趋势（厚度增加，然后变薄），但RNFL的变化先于影响脉络膜的变化。总之，我们的研究定量地证明了脉络膜在LHON病理中的参与。脉络膜厚度的增加是LHON急性期的特征，其跟随RNFL的增厚。相反，脉络膜变薄是慢性LHON和DOA的常见结果。
Leber's hereditary optic neuropathy (LHON) is typically characterized by vascular alterations in the acute phase. The aim of this study was to evaluate choroidal changes occurring in asymptomatic, acute and chronic stages of LHON. We enrolled 49 patients with LHON, 19 with Dominant Optic Atrophy (DOA) and 22 healthy controls. Spectral Domain-Optical Coherence Tomography (SD-OCT) scans of macular and peripapillary regions were performed in all subjects, to evaluate macular and peripapillary choroidal thickness, and retinal nerve fiber layer (RNFL) thicknes. Macular and peripapillary choroidal thicknesses were significantly increased in the acute LHON stage. On the contrary, macular choroidal thickness was significantly reduced in the chronic stage. Furthermore, peripapillary choroidal thickness was decreased in chronic LHON and in DOA. Both RNFL and choroid had the same trend (increased thickness, followed by thinning), but RNFL changes preceded those affecting the choroid. In conclusion, our study quantitatively demonstrated the involvement of the choroid in LHON pathology. The increase in choroidal thickness is a feature of the LHON acute stage, which follows the thickening of RNFL. Conversely, thinning of the choroid is the common outcome in chronic LHON and in DOA.