PERSISTING ILLNESS AND FATIGUE IN ADULTS WITH EVIDENCE OF EPSTEIN-BARR VIRUS-INFECTION
PERSISTING ILLNESS AND FATIGUE IN ADULTS WITH EVIDENCE OF EPSTEIN-BARR VIRUS-INFECTION
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DOI：
10.7326/0003-4819-102-1-7
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发表时间：
1985-01-01
影响因子：
39.2
通讯作者：
BLAESE, RM
中科院分区：
文献类型：
--
作者：
STRAUS, SE;TOSATO, G;BLAESE, RM
临床，血清学，病毒学和免疫学评价31例成人慢性疾病和疲劳表明，23例持续EB病毒感染。在这23例患者中，细胞免疫机制基本正常，但4例有轻度IG缺乏。患者（20例）具有EB病毒特异性异常血清学特征，表现为病毒衣壳抗原或早期抗原抗体滴度显著升高，或后期出现抗体缺乏。15例患者中有11例检测到循环免疫复合物，18例检测不到循环干扰素，但有5例患者的2-5寡腺苷酸合成酶（一种干扰素诱导的酶）活性升高。在19例患者中，18例具有持续抑制性T细胞活性，通常见于急性传染性单核细胞增多症恢复期患者。EB病毒可能与成人慢性疾病有关。
Clinical, serologic, virologic and immunologic evaluations for 31 adults with chronic illness and fatigue suggested that 23 had persisting Epstein-Barr virus infection. Among these 23 patients, cellular immune mechanisms were generally normal, but 4 had mild Ig deficiencies. Patients (20) had abnormal serologic profiles specific for Epstein-Barr virus shown by significantly elevated titers of antibodies to the viral capsid antigen or early antigen, or by a deficiency of late-appearing antibodies. In 11 of 15 patients tested, circulating immune complexes were found. Circulating interferon was not found in 18 patients tested, but the activity of 2-5 oligoadenylate synthetase, an interferon-induced enzyme, was increased in 5 patients studied. Of 19 patients, 18 had persisting suppressor T-cell activity typically found in patients recovering from acute infectious mononucleosis. The Epstein-Barr virus may be associated with chronic illness in adults.