Genetic control of intestinal stem cell specification and development: a comparative view.
Genetic control of intestinal stem cell specification and development: a comparative view.
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DOI：
10.1007/s12015-012-9351-1
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发表时间：
2012-06
影响因子：
4.8
通讯作者：
Hartenstein, Volker
中科院分区：
文献类型：
--
作者：
Takashima, Shigeo;Hartenstein, Volker
成体脊椎动物肠道的干细胞（ISCs）负责肠道细胞的持续更新，但也是肠道肿瘤的起源部位。包括Wnt/Wg、Shh/Hh、BMP和Notch在内的多种信号通路之间的相互作用协调了ISCs的有丝分裂、运动和分化。这些途径如何发挥其功能的许多基本问题仍然没有答案。获得更多见解的一种方法是观察干细胞的发育，分析这些细胞从大量胚胎祖细胞中出现时所经历的“编程”过程。本文综述了脊椎动物肠道干细胞生物学的相关研究资料，并对果蝇肠道干细胞发育的研究进展进行了综述。在这里，干细胞池和它们的小生境环境由相对少量的细胞组成，并且关于细胞分裂模式、小生境-干细胞接触或分化的问题可以在单细胞水平上解决。同样，与脊椎动物系统相比，可以更容易地分析发育过程中干细胞的出现：干细胞在胚胎中的哪里出现，它们与环境中的哪些结构相互作用，以及由于这些相互作用，哪些信号通路依次活跃。鉴于所有动物中控制干细胞行为的遗传机制之间的高度保守性，果蝇的发现将为脊椎动物干细胞领域的研究提供答案。
Stem cells of the adult vertebrate intestine (ISCs) are responsible for the continuous replacement of intestinal cells, but also serve as site of origin of intestinal neoplasms. The interaction between multiple signaling pathways, including Wnt/Wg, Shh/Hh, BMP, and Notch, orchestrate mitosis, motility, and differentiation of ISCs. Many fundamental questions of how these pathways carry out their function remain unanswered. One approach to gain more insight is to look at the development of stem cells, to analyze the “programming” process which these cells undergo as they emerge from the large populations of embryonic progenitors. This review intends to summarize pertinent data on vertebrate intestinal stem cell biology, to then take a closer look at recent studies of intestinal stem cell development in Drosophila. Here, stem cell pools and their niche environment consist of relatively small numbers of cells, and questions concerning the pattern of cell division, niche-stem cell contacts, or differentiation can be addressed at the single cell level. Likewise, it is possible to analyze the emergence of stem cells during development more easily than in vertebrate systems: where in the embryo do stem cells arise, what structures in their environment do they interact with, and what signaling pathways are active sequentially as a result of these interactions. Given the high degree of conservation among genetic mechanisms controlling stem cell behavior in all animals, findings in Drosophila will provide answers that inform research in the vertebrate stem cell field.
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影响因子：
29.4
作者：
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通讯作者：
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作者：
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