GABAERGIC NEURONS AND THEIR ROLE IN CORTICAL PLASTICITY IN PRIMATES
GABAERGIC NEURONS AND THEIR ROLE IN CORTICAL PLASTICITY IN PRIMATES
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DOI：
10.1093/cercor/3.5.361-a
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发表时间：
1993-09-01
期刊：
影响因子：
3.7
通讯作者：
JONES, EG
中科院分区：
文献类型：
--
作者：
JONES, EG
GABA神经元和GABA受体是大脑皮层组织的重要组成部分。它们的作用是塑造感觉区神经元的刺激-反应特性，毫无疑问，它们在非感觉区也发挥着类似的作用。虽然非GABA能局部回路神经元存在于大脑皮层中，但GABA能神经元所采用的多种形式及其重要的功能作用使后者在局部皮层回路的研究中受到关注。在灵长类动物的新皮质中，GABA能神经元占神经元群体的约25-30%。除了它们在形成神经元感受野和反应谱方面的已知或假定功能外（其中一些功能仍有争议（Sillito，1984; Ferster，1986）），它们的递质GABA及其作用的主要受体类别甚至在成人中也以活性依赖性方式受到调节（Jones，1990）。在这一点上，有一种潜在的表征地图可塑性机制，在躯体感觉、运动、听觉和视觉皮层中是可证明的（梅尔泽尼希等人，1983; Sanes等人，1988; Robertson和Irvine，1989; Kaas等人，1990年）。
GABA neurons and GABA receptors are conspicuous elements of cerebral cortical organization. They serve to shape the stimulus-response properties of neurons in the sensory areas and undoubtedly play a comparable role in the nonsensory areas as well. Although non-GABAergic local circuit neurons exist in the cerebral cortex, the variety of forms adopted by the GABAergic neurons and their important functional role have served to focus attention on the latter in investigations of local cortical circuitry. In primate neocortex, GABAergic neurons constitute approximately 25-30% of the neuronal population. In addition to their known or postulated functions in shaping neuronal receptive fields and response profiles, some of which are still controversial (Sillito, 1984; Ferster, 1986), their transmitter, GABA, and the major class of receptor upon which it acts are regulated in an activity-dependent manner even in the adult (Jones, 1990). In this, there is a potential mechanism for the plasticity of representational maps that is demonstrable in somatic sensory, motor, auditory, and visual cortex (Merzenich et al., 1983; Sanes et al., 1988; Robertson and Irvine, 1989; Kaas et al., 1990).