Post-operative neutrophil-lymphocyte ratio predicts complications following colorectal surgery.
Post-operative neutrophil-lymphocyte ratio predicts complications following colorectal surgery.
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DOI：
10.1016/j.ijsu.2006.05.013
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发表时间：
2007-02-01
期刊：
影响因子：
--
通讯作者：
Keeling, Neil J
中科院分区：
文献类型：
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作者：
Cook, Emily J;Walsh, Stewart R;Keeling, Neil J
简介：重症监护病房结直肠手术患者的嗜中性淋巴细胞比率（NLR）与系列器官功能障碍评分相关。我们假设，NLR后的第一天，选择性结直肠切除术将确定患者在随后的并发症的风险增加。方法：与伦理委员会批准，100例患者被招募到一个前瞻性队列研究。记录所有患者的术前检查结果和术后第一天的全血细胞计数。任何预定义的术后并发症的发展recorded.Results：择期结直肠切除术与平均NLR从3.5增加到11.6（p或=9.3）相关，术后第一天并发症的风险显著更大（似然比2.12; 95%置信区间1.366-3.253）。22例患者术后第一天的白色细胞计数≥ 11，但这与并发症风险显著增加无关（似然比1.94; 95%置信区间0.94-3.9）。结论：术后第一天的NLR ≥ 9.3与并发症风险增加相关。这种常规可用数据的简单推导有助于识别并发症高风险患者，从而采取有针对性的预防措施。
INTRODUCTION: The neutrophil-lymphocyte ratio (NLR) correlates with serial organ dysfunction scores in colorectal surgical patients in critical care units. We hypothesised that the NLR on the first day after an elective colorectal resection would identify patients at increased risk of subsequent complications.METHODS: With Ethics Committee approval, 100 patients were recruited to a prospective cohort study. Pre-operative test results and the full blood count on the first post-operative day were noted for all patients. The development of any pre-defined post-operative complications was recorded.RESULTS: Elective colorectal resection was associated with an increase in mean NLR from 3.5 to 11.6 (p or =9.3 on the first post-operative day had a significantly greater risk of complications (likelihood ratio 2.12; 95% confidence interval 1.366-3.253). Twenty-two patients had a white cell count > or =11 on the first post-operative day but this was not associated with a significantly increased risk of complications (likelihood ratio 1.94; 95% confidence interval 0.94-3.9).CONCLUSION: NLR > or =9.3 on the first post-operative day is associated with an increased risk of complications. This simple derivation of routinely available data helps to identify patients at high-risk of complications, allowing targeted preventive measures.