Body composition of lean and obese Zucker rats in parabiosis.
Body composition of lean and obese Zucker rats in parabiosis.
复制标题
联体共生中瘦和肥胖 Zucker 大鼠的身体成分。
DOI：
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发表时间：
1987
影响因子：
4.9
通讯作者：
G. Tobin
中科院分区：
文献类型：
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作者：
R. B. Harris;E. Hervey;G. Hervey;G. Tobin
异种共生是两种动物的外科结合，以产生慢性血液交换。这个模型以前曾被用来证明血液传播因素参与了食物摄入量的反馈控制和能量平衡的调节。据推测，肥胖大鼠会产生一种体液因子，这种物质主要作用于抑制食物的摄取和脂肪的积累。在这项研究中，出生50天的雄性或雌性Zucker大鼠被分成瘦-瘦对或瘦-肥胖对。他们随意进食，直到152天大时身体成分被确定。与单一对照相比，所有大鼠的异种共生都抑制了生长。肥胖大鼠的瘦身伴侣体重减轻，与瘦身配对的成员相比，身体蛋白质的百分比相同，但脂肪更少。雌性大鼠的身体成分比雄性大鼠的变化更大。这些结果表明，肥胖的Zucker大鼠产生了假想的调控信号，但没有反应。
Parabiosis is the surgical union of two animals to produce a chronic blood exchange. This model has previously been used to demonstrate the involvement of a blood-borne factor in the feedback control of food intake and regulation of energy balance. It has been hypothesized that obese rats produce a humoral agent that acts centrally to inhibit food intake and accumulation of fat. In this study 50-day-old male or female Zucker rats were joined in either lean-lean pairs or lean-obese pairs. They ate ad libitum until 152 days of age when body composition was determined. Parabiosis inhibited growth in all rats compared with single controls. Lean partners of obese rats had reduced carcass weights, the same percent body protein but less fat than members of lean-lean pairs. Female rats showed larger changes in body composition than did males. These results suggest that obese Zucker rats produce the hypothesized regulatory signal but do not respond to it.