Decrease in CD4+CD25+ and CD8+CD28+ T cells in interstitial pneumonitis associated with rheumatic disease
Decrease in CD4+CD25+ and CD8+CD28+ T cells in interstitial pneumonitis associated with rheumatic disease
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风湿病相关间质性肺炎中 CD4 CD25 和 CD8 CD28 T 细胞减少
DOI：
10.3109/s10165-008-0090-8
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发表时间：
2008
影响因子：
2.2
通讯作者：
Y. Takasaki
中科院分区：
文献类型：
--
作者：
A. Katagiri;S. Morimoto;Y. Nakiri;S. Nakano;A. Mitsuo;J. Suzuki;H. Amano;K. Nozawa;M. Asano;Y. Tokano;H. Hashimoto;Y. Takasaki
为了研究CD4+CD25+调节性T细胞和CD8+CD28−抑制性T细胞的状况，检测了与间质性肺炎（IP）相关的风湿性疾病患者T细胞上CD25或CD28的表达。55例各种风湿性疾病患者和23例正常对照。IP患者的CD4+CD25+ T细胞显著低于非IP患者，IP患者的CD8+CD28− T细胞比例显著高于非IP患者或正常对照。CD8+CD28− T细胞的这些结果与CD8+CD28+ T细胞的减少雅阁，并且可能与活化诱导的CD8+CD28+ T细胞死亡有关。因此，CD4+CD25+调节性T细胞的异常可能与IP的发病机制以及CD8+ T细胞的存活和活化有关。
The expression of CD25 or CD28 on T cells was examined in patients with rheumatic diseases associated with interstitial pneumonitis (IP), in order to investigate the conditions of CD4+CD25+ regulatory T cells and CD8+CD28− suppressor T cells. Fifty-five patients with various rheumatic diseases and 23 normal controls were enrolled. CD4+CD25+ T cells of patients with IP were significantly decreased in comparison with non-IP patients, and the ratio of CD8+CD28− T cells in patients with IP was significantly higher than that in non-IP patients or normal controls. These results for CD8+CD28− T cells were in accord with the decrease in CD8+CD28+ T cells, and may be related to activation-induced CD8+CD28+ T-cell death. Thus, the abnormality of CD4+CD25+ regulatory T cells may be related to the pathogenesis of IP, and the survival and activation of CD8+ T cells.
DOI：
10.1165/ajrcmb.24.5.4064
发表时间：
2001-05-01
影响因子：
6.4
作者：
Chen, ES;Greenlee, BM;Moller, DR
通讯作者：
Moller, DR
B 和 T 淋巴细胞上 CD22 配体表达的差异控制，以及小鼠系统性狼疮中表达的增强。
DOI：
10.1002/art.11021
发表时间：
2003
期刊：
Arthritis and rheumatism.
影响因子：
--
作者：
Lajaunias,Frederic;Ida,Akinori;Kikuchi,Shuichi;Fossati-Jimack,Liliane;Martinez-Soria,Eduardo;Moll,Thomas;Law,Che-Leung;Izui,Shozo
通讯作者：
Izui,Shozo
博莱霉素诱导的肺损伤中小鼠巨噬细胞炎症蛋白 1 α 的产生和功能。
DOI：
--
发表时间：
1994
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Smith,RE;Strieter,RM;Phan,SH;Lukacs,NW;Huffnagle,GB;Wilke,CA;Burdick,MD;Lincoln,P;Evanoff,H;Kunkel,SL
通讯作者：
Kunkel,SL