SEROTONIN UPTAKE SITES AND SEROTONIN RECEPTORS ARE ALTERED IN THE LIMBIC SYSTEM OF SCHIZOPHRENICS
SEROTONIN UPTAKE SITES AND SEROTONIN RECEPTORS ARE ALTERED IN THE LIMBIC SYSTEM OF SCHIZOPHRENICS
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DOI：
10.1038/npp.1993.32
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发表时间：
1993-06-01
影响因子：
7.6
通讯作者：
KLEINMAN, JE
中科院分区：
文献类型：
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作者：
JOYCE, JN;SHANE, A;KLEINMAN, JE
用放射自显影方法，用[H-3]氰基丙咪胺([H-3]CN-IMI)、含[H-3]8-羟基-2-[二正丙氨基]四氢萘([H-3]8-OH-DPAT)的5-HT1a受体、含[H-3]酮丝氨酸和[I-125]麦角酸二乙胺([I-125]LSD)的5-HT2受体，对8例非神经科对照组和10例诊断为精神分裂症患者的5-羟色胺(5-HT)摄取部位进行了定位。在纹状体中，5-羟色胺摄取部位有明显的异质性，这与纹状体的纹状体/基质区划相对应。这种组织与5-HT2或5-HT1a受体的异质性模式不匹配。对于等皮质，5-HT1a受体在外板和深板高表达，而5-HT2受体在内板高表达。5-羟色胺摄取部位呈层状分布，接近5-HT1a受体和5-HT2受体的组合分布。在海马旁回和海马区，5-羟色胺摄取部位的分布与5-HT1a和5-HT2受体的分布是互补的。精神分裂症患者纹状体5-羟色胺摄取部位数目增加，纹状体/基质结构改变。精神分裂症患者伏隔核和腹侧壳核的5-HT2受体数量也增加。5-HT1a受体的数量没有改变。前扣带回、额叶皮质和后扣带回的外板和中板的5-羟色胺摄取部位明显减少，运动皮质、颞叶皮质和海马区的5-羟色胺摄取部位无明显变化。5-HT1a受体在后扣带回、运动皮质和海马区的数量增加。血清素2受体在后扣带回、颞叶皮质和海马区显著升高，但在额叶、前扣带回或运动皮质无明显升高。对一组非精神分裂症自杀者(n=8)的颞叶和海马区的检查表明，精神分裂症患者纹状体边缘区、边缘皮质和海马区5-羟色胺系统的改变可能是疾病特异性的。
Serotonin (5-HT) uptake sites were mapped by autoradiographic means with [H-3]cyano-imipramine ([H-3]CN-IMI), the 5-HT1A receptor with [H-3]8-hydroxy-2-[di-n-propyl-amino]tetralin ([H-3]8-OH-DPAT), and the 5-HT2 receptor with both [H-3]ketanserin and [I-125]lysergic acid diethylamide ([I-125]LSD) in eight nonneurologic controls and 10 cases with a diagnosis of schizophrenia. In the striatum, there was a marked heterogeneous patterning of 5-HT uptake sites that corresponded to the striosomal/matrix compartmentalization of the striatum. This organization was not matched with an equally heterogeneous pattern of either 5-HT2 or 5-HT1A receptors. For the isocortex, a general organizational scheme was observed with the 5-HT1A receptor expression high in the external laminae and deep laminae, but 5-HT2 receptor expression was higher in the internal laminae. There was a laminar distribution of 5-HT uptake sites that approximated the combined distributions of the 5-HT1A receptor and the 5-HT2 receptor. In the parahippocampal gyrus and hippocampus, the distribution of 5-HT uptake sites was complementary to the distribution of 5-HT1A and 5-HT2 receptors. In schizophrenic cases, there was a large increase in the number and altered striosomal/matrix organization of 5-HT uptake sites in the striatum. There was also an increase in the numbers of 5-HT2 receptors in the nucleus accumbens and ventral putamen of the schizophrenics. The number of 5-HT1A receptors was not modified. There was a marked reduction in 5-HT uptake sites in the external and middle laminae of the anterior cingulate, frontal cortex, and posterior cingulate, and no changes were observed in the motor cortex, temporal cortex, or hippocampus. Increased numbers of 5-HT1A receptors were found in the posterior cingulate, motor cortex, and hippocampus. Serotonin2 receptors were substantially elevated in the posterior cingulate, temporal cortex, and hippocampus, but not in the frontal, anterior cingulate, or motor cortices. Examination of the temporal lobe and hippocampus of a group of nonschizophrenic suicides (n = 8) indicated the alterations in 5-HT system in the limbic regions of the striatum, the limbic cortex, and hippocampus of the schizophrenic cases may be disease specific.