320-Channel Active Probe for High-Resolution Neuromonitoring and Responsive Neurostimulation
320-Channel Active Probe for High-Resolution Neuromonitoring and Responsive Neurostimulation
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DOI：
10.1109/tbcas.2014.2312552
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发表时间：
2015-02-01
影响因子：
5.1
通讯作者：
Genov, Roman
中科院分区：
文献类型：
--
作者：
Shulyzki, Ruslana;Abdelhalim, Karim;Genov, Roman
我们提出了一个320通道的高空间分辨率的神经监测和反应性神经刺激的主动探头。该探针包括集成电路（IC）单元阵列，其结合到间距匹配的微电极阵列的背面。该集成电路可以分别以400 μ m和200 μ m的空间分辨率进行多达256个位点的神经记录和64个位点的神经刺激。它适合于与柄节距为200 μ m的整数倍的电极阵列直接集成。在所提出的配置中，IC与8 × 8 400 μ m间距的犹他州电极阵列（UEA）结合，并且多达192个额外的记录通道用于外周神经监测。0.35 μ m CMOS电路阵列的总芯片尺寸为3.5 mm × 3.65 mm。每个刺激器通道采用电流存储器进行同时多部位神经刺激，输出20 μ A-250 μ A方波或任意波形电流，占用0.02 mm（2），消耗2.76 μ W静态功率。每个全差分记录通道具有两级放大和滤波以及一个8位单斜率ADC，占用0.035mm（2），消耗51.9 μ W。该神经探针已在体外小鼠海马切片的癫痫发作传播研究和体内急性癫痫大鼠模型中抑制癫痫发作的响应性神经刺激中得到实验验证。
We present a 320-channel active probe for high-spatial-resolution neuromonitoring and responsive neurostimulation. The probe comprises an integrated circuit (IC) cell array bonded to the back side of a pitch-matched microelectrode array. The IC enables up to 256-site neural recording and 64-site neural stimulation at the spatial resolution of 400 mu m and 200 mu m, respectively. It is suitable for direct integration with electrode arrays with the shank pitch of integermultiples of 200 mu m. In the presented configuration, the IC is bonded with a 8 x 8 400 mu m-pitch Utah electrode array (UEA) and up to additional 192 recording channels are used for peripheral neuromonitoring. The 0.35 mu m CMOS circuit array has a total die size of 3.5 mm x 3.65 mm. Each stimulator channel employs a current memory for simultaneous multi-site neurostimulation, outputs 20 mu A-250 mu A square or arbitrary waveformcurrent, occupies 0.02 mm(2), and dissipates 2.76 mu Wquiescent power. Each fully differential recording channel has two stages of amplification and filtering and an 8-bit single-slope ADC, occupies 0.035mm(2), and consumes 51.9 mu W. The neural probe has been experimentally validated in epileptic seizure propagation studies in a mouse hippocampal slice in vitro and in responsive neurostimulation for seizure suppression in an acute epilepsy rat model in vivo.