Experimental analysis of the role of the ZPA in the development of the wing buds of wingless (ws) mutant embryos.
Experimental analysis of the role of the ZPA in the development of the wing buds of wingless (ws) mutant embryos.
复制标题
ZPA在无翅(ws)突变体胚胎翅芽发育中作用的实验分析。
DOI：
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复制
发表时间：
1985
期刊：
影响因子：
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通讯作者：
J. Hinchliffe
中科院分区：
文献类型：
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作者：
D. Wilson;J. Hinchliffe
无翅鸡胚的表型特征是，从第19期开始，间充质细胞死亡向前后方向扩散。有人认为，这可能反映了功能极化区（ZPA）的缺失。无翅zpa（18-19期）与正常翼芽（20-21期）进行前轴接枝试验，结果表明无翅zpa与正常翼芽具有相同的复制特性。同样，将正常雏鸡或鹌鹑的ZPA（20-22期）移植到无翼翼芽（18-20期）的后缘，也没有抑制细胞死亡的模式，也没有引起其发育性能的任何改善。因此，无翼（ws）状况不是由于ZPA缺陷。可能的解释是无翼间质细胞死亡的预先编程，或体细胞缺陷，但似乎更有可能的是突变的肢体间质无法传递或响应由ZPA产生的因子。
Phenotypically wingless (ws) chick embryos have wing buds characterized by the spreading of mesenchymal cell death in an anterior-to-posterior direction beginning at stage 19. It has been argued that this may reflect the absence of a functional polarizing zone (ZPA). When tested by preaxial grafting into normal wing buds (stages 20-21), wingless ZPAs (stage 18-19) had duplicating properties identical with those of normal ZPAs. Equally, normal chick or quail ZPA (stages 20-22) grafted into the posterior margin of wingless wing buds (stages 18-20) failed to inhibit the pattern of cell death or to evoke any improvement in their developmental performance. The wingless (ws) condition is not, therefore, due to a ZPA deficiency. Possible explanations are the prior programming for cell death of the wingless mesenchyme, or somitic deficiency, but it appears more likely that the mutant limb mesenchyme fails to transmit or respond to factor(s) produced by the ZPA.
无翅突变鸡胚胎肢体发育的精细结构分析。
DOI：
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发表时间：
1982
期刊：
Journal of embryology and experimental morphology
影响因子：
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作者：
Sawyer,LM
通讯作者：
Sawyer,LM