Microstructure of temporo-parietal white matter as a basis for reading ability: Evidence from diffusion tensor magnetic resonance imaging
Microstructure of temporo-parietal white matter as a basis for reading ability: Evidence from diffusion tensor magnetic resonance imaging
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DOI：
10.1016/s0896-6273(00)80911-3
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发表时间：
2000-02-01
期刊：
影响因子：
16.2
通讯作者：
Poldrack, RA
中科院分区：
文献类型：
--
作者：
Klingberg, T;Hedehus, M;Poldrack, RA
采用扩散张量磁共振成像（MRI）研究阅读能力差或正常成人白色物质的微结构完整性。阅读困难的受试者双侧颞顶白色物质的弥散各向异性降低，这些区域的轴突主要是前后方向的。在T1加权MRI信号没有差异，发现穷人的读者和对照组之间，证明组差异的扩散张量成像（DTI）测量的显微结构特征的特异性。在阅读障碍的成年人和对照组中，左半球颞顶区的白色物质扩散各向异性与阅读分数显著相关。各向异性反映了白色物质束的微观结构，其可能通过确定参与视觉、听觉和语言处理的皮层区域之间的通信强度而有助于阅读能力。
Diffusion tensor magnetic resonance imaging (MRI) was used to study the microstructural integrity of white matter in adults with poor or normal reading ability. Subjects with reading difficulty exhibited decreased diffusion anisotropy bilaterally in temporoparietal white matter, Axons in these regions were predominantly anterior-posterior in direction. No differences in T1-weighted MRI signal were found between poor readers and control subjects, demonstrating specificity of the group difference to the microstructural characteristics measured by diffusion tensor imaging (DTI). White matter diffusion anisotropy in the temporo-parietal region of the left hemisphere was significantly correlated with reading scores within the reading-impaired adults and within the control group. The anisotropy reflects microstructure of white matter tracts, which may contribute to reading ability by determining the strength of communication between cortical areas involved in visual, auditory, and language processing.