PORTAL-HYPERTENSION AND PRIMARY BILIARY-CIRRHOSIS
PORTAL-HYPERTENSION AND PRIMARY BILIARY-CIRRHOSIS
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DOI：
10.1159/000197934
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发表时间：
1976-01-01
期刊：
影响因子：
3.2
通讯作者：
BENHAMOU, JP
中科院分区：
文献类型：
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作者：
LEBREC, D;SICOT, C;BENHAMOU, JP
门静脉高压症是原发性胆汁性肝硬化（PBC）的一种少见的晚期并发症。对24例PBC患者进行了门静脉高压症检查。食管静脉曲张出现在20，50和90%的患者1，3和9年，分别在发病后的肠炎和/或黄疸。11例门静脉高压症导致消化道出血，其中2例以出血为PBC的第一临床表现。无论有无再生结节，所有门脉高压症患者的肝静脉楔压均升高。5例行门腔静脉分流术，其中3例耐受良好。门脉高压在PBC中很常见，肝内阻滞是所谓的窦后型，即使在没有再生结节的患者中也是如此。门静脉高压症引起的消化道出血约占一半，可能是PBC的首发症状。当消化道出血发生在疾病的早期阶段时，门腔静脉分流术似乎是指征。
Portal hypertension was regarded as an uncommon and late complication of primary biliary cirrhosis (PBC). Patients (24) with PBC were investigated for portal hypertension. Esophageal varices were present in 20, 50 and 90% of the patients 1, 3 and 9 yr, respectively, after the onset of pruritis and/or jaundice. Portal hypertension was responsible for gastrointestinal bleedings in 11 patients; bleeding was the 1st clinical manifestation of PBC in 2 of them. Wedged hepatic venous pressure was increased in all the patients with portal hypertension whether regenerative nodules were present or absent. Portacaval shunt was performed in 5 patients and was well tolerated in 3 of them. Portal hypertension is common in PBC; the intrahepatic block is of the so-called postsinusoidal type, even in patients without regenerative nodules. Gastrointestinal bleeding due to portal hypertension occurs in about half of the patients and may be the 1st manifestation of PBC. A portacaval shunt seems to be indicated when gastrointestinal bleeding occurs in earlier stage of the disease.