SYSTEMATIC POPULATION-BASED ASSESSMENT OF CANCER RISK IN FIRST-DEGREE RELATIVES OF CANCER PROBANDS
SYSTEMATIC POPULATION-BASED ASSESSMENT OF CANCER RISK IN FIRST-DEGREE RELATIVES OF CANCER PROBANDS
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DOI：
10.1093/jnci/86.21.1600
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发表时间：
1994-11-02
期刊：
影响因子：
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通讯作者：
SKOLNICK, MH
中科院分区：
文献类型：
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作者：
GOLDGAR, DE;EASTON, DF;SKOLNICK, MH
背景：长期以来，癌症被认为具有家族性。据报道，癌症先证者的亲属在同一部位患癌症的风险增加，无论是常见癌症还是一些罕见的癌症部位。然而，对于一个特定的癌症部位，亲属的估计风险有很大的差异，这取决于先证者的选择标准，亲属中癌症的确定方式以及整体研究设计。毫不奇怪，在特定部位患癌先证者的亲属中，其他癌症的估计风险会有更大的变化。目的：本研究的目的是利用犹他州人口数据库资源系统地研究癌症先证者一级亲属（父母、兄弟姐妹和后代）中28个不同癌症部位定义的家族聚集性。方法：我们从犹他州人口数据库中通过确定这些一级亲属中所有癌症病例来估计家族相对风险。将这些观察值与根据犹他州人口数据库中已知在犹他州死亡的所有个体的399786名亲属计算的群体特异性内部比率的预期值进行比较。结果如下：所有地点都显示亲属中同一地点的癌症过多，甲状腺癌和结肠癌以及淋巴细胞白血病显示出最高的家族风险。当分析仅限于诊断时年龄较早的病例时，大多数癌症部位的家族性成分增加变得明显。男性（FRR = 4.04; 95%CI = 3.13-5.07）和女性（FRR = 2.24; 95%CI = 1.54-3.08）先证者之间的结肠癌家族相对危险度（FRR）存在显著差异。高度显著的家族关联（单侧; P
Background: Cancer has long been recognized to have a familial component. Elevated risks for cancers at the same site for relatives of cancer probands have been reported for both common cancers and a number of the rarer cancer sites. For a particular cancer site, however, the estimated risks to relatives have varied considerably depending on criteria for selection of probands, how cancers were determined in relatives, and overall study design. Not surprisingly, the estimated risks of other cancers in relatives of probands with cancer at a given site have been subject to even more variation. Purpose: The aim of this study was to use the Utah Population Database resource to systematically study familial clustering of 28 distinct cancer site definitions among first-degree relatives (parents, siblings, and offspring) of cancer probands. Methods: We estimated familial relative risks from the Utah Population Database by identifying all cases of cancer in these first-degree relatives. These observed values were compared with those expected based on cohort-specific internal rates calculated from 399 786 relatives of all individuals in the Utah Population Database known to have died in Utah. Results: All sites showed an excess of cancers of the same site among relatives, with thyroid and colon cancers and lymphocytic leukemia showing the highest familial risks. When the analyses were restricted to cases with early ages at diagnosis, increased familial components for most cancer sites became evident. A significant difference in familial relative risk (FRR) between male (FRR = 4.04; 95% confidence interval [CI] = 3.13-5.07) and female (FRR = 2.24; 95% CI = 1.54-3.08) probands was found for colon cancer. Highly significant familial associations (one-sided; P