Signaling pathways critical for allergic airway inflammation.
Signaling pathways critical for allergic airway inflammation.
复制标题
DOI：
10.1097/aci.0b013e328334f642
复制
发表时间：
2010-02
影响因子：
2.8
通讯作者：
Hankel IL
中科院分区：
文献类型：
--
作者：
Colgan JD;Hankel IL
活化的肥大细胞、嗜碱性粒细胞和CD 4+辅助性T细胞在过敏性炎症中具有关键作用。因此，设计特异性抑制这些细胞的方法可能有助于控制过敏性炎症。我们总结了最近的研究结果，肥大细胞和嗜碱性粒细胞在过敏反应和调节下游的IgE受体，肥大细胞和嗜碱性粒细胞活化的主要诱导剂的信号通路的作用。我们还强调了蛋白酪氨酸激酶Zap-70和Itk在免疫系统发育和调节CD 4+辅助T细胞反应中的作用的研究。最近的研究表明，肥大细胞的功能是出乎意料的多样性，嗜碱性粒细胞在Th 2型免疫应答中的作用比以前认识到的更突出。IgE受体信号通路的生化分析已经导致了关于磷酸酶和其他酶在该过程中的作用的见解。Zap-70和Itk的研究有助于确定抑制这些酶以抑制过敏性炎症的潜在结果和并发症。对基因工程小鼠的分析和生物化学研究继续有助于解开驱动过敏性炎症反应的分子途径。获得的知识可能会导致抑制过敏性炎症的新方法。
Activated mast cells, basophils, and CD4+ helper T cells have critical roles in allergic inflammation. Therefore, devising ways to specifically inhibit these cells will likely be useful for controlling allergic inflammation. We summarize recent findings regarding the role of mast cells and basophils in allergic responses and the regulation of signaling pathways downstream the IgE receptor, the chief inducer of mast cell and basophil activation. We also highlight studies addressing the roles of the protein tyrosine kinases Zap-70 and Itk in immune system development and in the regulation of CD4+ helper T cell responses. Recent work has demonstrated that mast cell function is unexpectedly diverse and that basophils have a more prominent role in Th2-type immune responses than previously appreciated. Biochemical analysis of the IgE receptor signaling pathway has led to insights regarding the roles of phosphatases and other enzymes in this process. Studies of Zap-70 and Itk have helped to define the potential outcomes and complications of inhibiting these enzymes in order to suppress allergic inflammation. Analysis of genetically engineered mice and biochemical studies continue to help unravel the molecular pathways that drive allergic inflammatory reactions. The knowledge acquired may lead to novel approaches for suppressing allergic inflammation.