A functional polyester carrying free hydroxyl groups promotes the mineralization of osteoblast and human mesenchymal stem cell extracellular matrix
A functional polyester carrying free hydroxyl groups promotes the mineralization of osteoblast and human mesenchymal stem cell extracellular matrix
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携带游离羟基的功能性聚酯促进成骨细胞和人间充质干细胞细胞外基质的矿化
DOI：
10.1016/j.actbio.2014.02.018
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发表时间：
2014-06-01
影响因子：
9.7
通讯作者：
Wang, Yadong
中科院分区：
文献类型：
--
作者：
Bi, Xiaoping;You, Zhengwei;Wang, Yadong
官能团可以控制生物界面，并提供一种简单的方法来制造治疗材料。我们最近报道的设计和合成的聚（癸二酰甘油二酯）（PSeD）进行了一个自由的羟基在其重复单元。本文探讨了使用这种聚合物，以促进生物矿化的骨组织工程的应用。PSeD促进人骨髓间充质干细胞和大鼠成骨细胞分泌的细胞外基质的矿化作用比目前广泛应用于骨组织工程的聚乳酸-羟基乙酸共聚物（PLGA）更强。PSeD显示出与PLGA相当或更好的体外骨相容性和体内生物相容性，并支持大鼠成骨细胞和人间充质干细胞的附着、增殖和分化。这证明了PSeD用于骨再生的潜力。(C)2014 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Functional groups can control biointerfaces and provide a simple way to make therapeutic materials. We recently reported the design and synthesis of poly(sebacoyl diglyceride) (PSeD) carrying a free hydroxyl group in its repeating unit. This paper examines the use of this polymer to promote biomineralization for application in bone tissue engineering. PSeD promoted more mineralization of extracellular matrix secreted by human mesenchymal stem cells and rat osteoblasts than poly(lactic-co-glycolic acid) (PLGA), which is currently widely used in bone tissue engineering. PSeD showed in vitro osteocompatibility and in vivo biocompatibility that matched or surpassed that of PLGA, as well as supported the attachment, proliferation and differentiation of rat osteoblasts and human mesenchymal stem cells. This demonstrates the potential of PSeD for use in bone regeneration. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.