Structural Genomics of SARS-CoV-2 Indicates Evolutionary Conserved Functional Regions of Viral Proteins
Structural Genomics of SARS-CoV-2 Indicates Evolutionary Conserved Functional Regions of Viral Proteins
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DOI：
10.3390/v12040360
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发表时间：
2020-04-01
期刊：
影响因子：
4.7
通讯作者：
Korkin, Dmitry
中科院分区：
文献类型：
--
作者：
Srinivasan, Suhas;Cui, Hongzhu;Korkin, Dmitry
在最初的两个半月里，最近出现的2019年新型冠状病毒-SARS-CoV-2已经感染了全球超过10万人，夺走了4000多人的生命。然而，这种迅速传播的病毒也引起了研究界前所未有的快速反应，面临着潜在巨大的未知健康挑战。不幸的是，了解病毒感染背后的分子机制并设计疫苗或抗病毒药物的实验研究成本高昂，需要数月时间才能开发出来。为了加快我们知识的发展，我们利用了公共数据库中容易获得的有关冠状病毒的数据，并将这些数据整合到一个单一的计算管道中。因此，我们提供了SARS-CoV-2的全面结构基因组学和相互作用路线图，并利用这些信息来推断与相关SARS冠状病毒可能的功能差异和相似之处。所有数据都向研究界公开。
During its first two and a half months, the recently emerged 2019 novel coronavirus, SARS-CoV-2, has already infected over one-hundred thousand people worldwide and has taken more than four thousand lives. However, the swiftly spreading virus also caused an unprecedentedly rapid response from the research community facing the unknown health challenge of potentially enormous proportions. Unfortunately, the experimental research to understand the molecular mechanisms behind the viral infection and to design a vaccine or antivirals is costly and takes months to develop. To expedite the advancement of our knowledge, we leveraged data about the related coronaviruses that is readily available in public databases and integrated these data into a single computational pipeline. As a result, we provide comprehensive structural genomics and interactomics roadmaps of SARS-CoV-2 and use this information to infer the possible functional differences and similarities with the related SARS coronavirus. All data are made publicly available to the research community.