Cutaneous small vessel vasculitis: an entity with frequent renal involvement.
Cutaneous small vessel vasculitis: an entity with frequent renal involvement.
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皮肤小血管炎：一种频繁累及肾脏的疾病。
DOI：
10.1002/art.1780390224
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发表时间：
2002
影响因子：
--
通讯作者：
A. Tosca
中科院分区：
文献类型：
--
作者：
D. Ioannidou;K. Krasagakis;E. Daphnis;K. Perakis;F. Sotsiou;A. Tosca
系统性血管病变是多发性骨髓瘤 (MM) 的罕见并发症。我们描述了一名诊断为 MM 的患者，其出现全身性血管病变的临床特征，包括坏疽、网状青斑、高血压、肾功能衰竭和小肠穿孔。小肠的组织病理学检查显示小动脉中存在坏死性血管炎，以及小血管中的结晶沉积物。据我们所知，之前报道的与多发性骨髓瘤相关的系统性血管病变病例中，至少有 9 例是由于血管内晶体球蛋白沉积所致，2 例是由于结节性多动脉炎所致。晶体球蛋白的沉积物可能诱发了我们患者的全身性坏死性血管炎。
Systemic vasculopathy is a rare complication of multiple myeloma (MM). We describe a patient diagnosed with MM who developed clinical features of systemic vasculopathy including gangrene, livedo reticularis, hypertension, renal failure, and perforation of the small intestine. Histopathologic examination of the small intestine revealed necrotizing vasculitis in the small arteries, along with crystalline deposits in the small vessels. To our knowledge, previously reported cases of systemic vasculopathy associated with MM include at least 9 cases due to crystalglobulin deposition in vessels and 2 due to polyarteritis nodosa. Deposits of crystalglobulin may have induced systemic necrotizing vasculitis in our patient.