Effect of 1 alpha, 24(R)-dihydroxyvitamin D3 on calcium metabolism in the rat.
Effect of 1 alpha, 24(R)-dihydroxyvitamin D3 on calcium metabolism in the rat.
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1 α, 24(R)-二羟基维生素 D3 对大鼠钙代谢的影响。
DOI：
10.1530/acta.0.1110572
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
H. Fleisch
中科院分区：
文献类型：
--
作者：
S. Yamada;J. Bonjour;H. Fleisch
已经表明，1 α，24（R）-二羟基维生素D3（1，24（OH）2D 3），一种化学合成的维生素D类似物，可能具有增强全身Ca保留的特性，因此可能用于骨质疏松症。为了验证这一假设，在维生素D充足的大鼠中，以25、50和100 pmol的每日剂量ip注射1.24（OH）2D 3，持续10天，测量钙代谢的主要通量。与成对喂养的对照动物相比，用1，24（OH）2D 3处理的大鼠显示出钙的净肠吸收和钙的尿排泄显著增加，骨吸收增加，但骨形成没有显著变化。全身钙潴留在25 pmol/天时没有变化，在50和100 pmol/天时显示出降低的趋势。总之，这些结果并不表明在可用的维生素D类似物中，1，24（OH）2D 3对于增加骨质疏松症中的骨钙潴留特别有用。
It has been suggested that 1 alpha, 24(R)-dihydroxyvitamin D3 (1,24(OH)2D3), a chemically synthesized vitamin D analogue, may have the property to enhance whole-body Ca retention and may thus be of use in osteoporosis. In order to test this hypothesis the main fluxes of Ca metabolism were measured in vitamin D-replete rats injected ip with 1.24(OH)2D3 at daily doses of 25, 50 and 100 pmol for 10 days. As compared with pair fed control animals, rats treated with 1,24(OH)2D3 displayed a significant rise in net intestinal absorption of Ca and in urinary excretion of Ca, and increase in bone resorption but no significant change in bone formation. Whole body Ca retention was not changed at 25 pmol/day and showed a trend to decrease at 50 and 100 pmol/day. In conclusion these results do not suggest that among available vitamin D analogues, 1,24(OH)2D3 would be particularly useful for increasing bone Ca retention in osteoporosis.