Childhood monosomy 7 syndrome
Childhood monosomy 7 syndrome
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儿童7号单体综合症
DOI：
10.1002/ajh.2830130409
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发表时间：
1982
影响因子：
12.8
通讯作者：
L. Forest
中科院分区：
文献类型：
--
作者：
M. Gyger;Y. Bonny;L. Forest
近年来，各种血液病的染色体畸变引起了极大的兴趣。事实上，一些非随机染色体异常现在被认为是造成特定类型造血障碍的原因，而其他染色体异常则与特征性血液学特征密切相关。单体C，后来通过不同的显带方法显示为单体7，在儿童中与一种特殊的骨髓增生性疾病有关。对文献中发表的早期病例的回顾性分析和我们希望报告的最近观察结果表明，单体7最一致的表型表达是对与白血病前期造血障碍相关的细菌感染的易感性增加。急性非淋巴细胞白血病是这种特殊的白血病前期综合征的终末事件，因此表明单体7涉及已经致力于髓细胞分化的干细胞。
In recent years, chromosomal aberrations in various hematologic disorders have raised a great deal of interest. In fact, several nonrandom chromosomal abnormalities are now recognized to be responsible for a specific type of dyshemopoiesis while others are closely associated with characteristic hematologic features. Monosomy C, later shown to be monosomy 7 by different banding methods, has been described in children in relation to a peculiar myeloproliferative disorder. Retrospective analysis of early cases published in the literature and a recent observation that we wish to report suggest that the most consistent phenotypic expression of monosomy 7 is an increased susceptibility to bacterial infections related to a preleukemic dyshemopoiesis. Acute nonlymphocytic leukemia is the terminal event of this peculiar preleukemic syndrome, and thus suggests that monosomy 7 involves a stem cell already committed to myeloid differentiation.
急性白血病细胞遗传学异常的意义。
影响因子：
3.3
作者：
Golomb,HM;Rowley,JD
通讯作者：
Rowley,JD
儿童白血病前期。
DOI：
10.1016/s0022-3476(81)80761-5
发表时间：
1981
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Blank,J;Lange,B
通讯作者：
Lange,B