Osmoregulation and renal effects of vasopressin in normal and mildly hypertensive subjects.
Osmoregulation and renal effects of vasopressin in normal and mildly hypertensive subjects.
复制标题
加压素对正常和轻度高血压受试者的渗透调节和肾脏影响。
作者：
M. Thibonnier;P. Sassano;S. Daufresne;P. Corvol;J. Ménard
对 10 名血压正常的志愿者和 10 名轻度高血压受试者进行 2 小时 0.85 M 高渗盐水输注，以比较这两组中加压素的渗透调节以及该激素对血压的影响。尽管加压素水平显着升高，但两组均未观察到血压显着变化。在对照组（AVP = -70 + 0.25 POsm，r = 0.68，P 小于 0.0001）和高血压组（AVP = -46 + 0.16 POsm，r = 0.59，P 小于0.0001）中，血浆加压素（AVP）和血浆渗透压（POsm）之间存在显着正相关性。然而，高血压受试者的加压素对渗透压刺激的反应受到缓冲。高血压受试者的血浆加压素和血浆渗透压之间的回归线的斜率比正常血压受试者的斜率要小（0.16 vs. 0.25，P 小于 0.018）。在盐水输注期间，两组的肾脏参数相同。最后，在轻度高血压中，加压素的渗透压调节得以保留，但受到缓冲，肾脏对该激素的敏感性正常。渗透压诱导的加压素生理性增加不会导致血压正常或轻度高血压受试者的血压升高。
A 2-hr 0.85 M hypertonic saline infusion was administered to ten normotensive volunteers and ten mildly hypertensive subjects to compare in these two groups the osmoregulation of vasopressin and the effect of this hormone on BP. No significant alteration in BP was observed in either group, despite markedly enhanced vasopressin levels. Significant positive correlations between plasma vasopressin (AVP) and plasma osmolality (POsm) were demonstrated in the controls (AVP = -70 + 0.25 POsm, r = 0.68, P less than 0.0001) and in the hypertensive group (AVP = -46 + 0.16 POsm, r = 0.59, P less than 0.0001). However, the vasopressin response to the osmotic stimulus was buffered in the hypertensive subjects; the slope of the regression line between plasma vasopressin and plasma osmolality was less steep in hypertensive subjects than in normotensive subjects (0.16 vs. 0.25, P less than 0.018). During the saline infusion the renal parameters were identical in the two groups. Finally, in mild hypertension, the osmoregulation of vasopressin was preserved but buffered and renal sensitivity to this hormone was normal. An osmotically induced physiological increase in vasopressin did not raise BP in either normotensive or mildly hypertensive subjects.