Turnover of naive- and memory-phenotype T cells.
Turnover of naive- and memory-phenotype T cells.
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幼稚和记忆 - 表型T细胞的营业额。
DOI：
10.1084/jem.179.4.1127
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发表时间：
1994-04-01
期刊：
影响因子：
--
通讯作者：
Sprent J
中科院分区：
文献类型：
--
作者：
Tough DF;Sprent J
基于它们的表面标记，T淋巴细胞被分为"初始"和"记忆细胞"的亚群。我们已经定义了幼稚和记忆T细胞的相互关系和相对寿命，通过检查小鼠T细胞的表面标志物，将溴脱氧尿苷，DNA前体，在饮用水中。报告了三项调查结果。首先，使用一种新的方法，我们表明，新形成的幼稚T细胞从未经处理的胸腺释放是非常低的（证实了其他人的发现与手术方法）。第二，在胸腺切除小鼠中，具有幼稚表型的T细胞在间期保持较长的时间;然而，这些细胞中的一些分裂并保留（或重新获得）它们的"幼稚"标记。第三，大多数具有记忆表型的T细胞迅速分裂，但其他T细胞仍处于间期数周。总的来说，数据表明，长寿的T细胞具有多种表型，并含有记忆细胞，幼稚（原始）细胞和伪装成幼稚细胞的记忆细胞的混合物。
On the basis of their surface markers, T lymphocytes are divided into subsets of "naive" and "memory cells". We have defined the interrelationship and relative life spans of naive and memory T cells by examining the surface markers on murine T cells incorporating bromodeoxyuridine, a DNA precursor, given in the drinking water. Three findings are reported. First, using a new method we show that the release of newly formed naive T cells from the unmanipulated thymus is very low (confirming the findings of others with surgical approaches). Second, in thymectomized mice, T cells with a naive phenotype remain in interphase for prolonged periods; however, some of these cells divide and retain (or regain) their "naive" markers. Third, most T cells with a memory phenotype divide rapidly, but others remain in interphase for many weeks. Collectively, the data indicate that long-lived T cells have multiple phenotypes and contain a mixture of memory cells, naive (virgin) cells, and memory cells masquerading as naive cells.